Human QKI Recombinant Protein – Cat# MBS144865

QKI Human Recombinant Protein

Name: QKI Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144865
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144865

Description: LBH Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids (1-105 a.a) and having a molecular mass of 14.6kDa.LBH is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

QKI, Recombinant Protein

Full Product Name

Recombinant Human QKI

Product Gene Name

QKI recombinant protein

Product Synonym Names

QKI Human; QKI Human Recombinant; Hqk; hqkI; QK; QK1; QK3; Protein quaking; Quaking

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMVG EMET KEKPKPTPDY LMQLMNDKKL MSSLPNFCGI FNHLERLLDE EISRVRKDMY NDTLNGSTEK RSAELPDAVG PIVQLQEKLY VPVKEYPDFN FVGRILGPRG LTAKQLEAET GCKIMVRGKG SMRDKKKEEQ NRGKPNWEHL NEDLHVLITV EDAQNRAEIK LKRAVEEVKK LLVPAAEGED SLKKMQLMEL AILNGTYRDA NIKSPALAFS LAATAQAAPR IITGPAPVLP PAALRTPTPA GPTIMPLIRQ IQTAVMPNGT PHPTAAIVPP GPEAGLIYTP YEYPYTLAPA TSILEYPIEP SGVLGAVATK VRRHDMRVHP YQRIVTADRA ATGN

Host

E Coli

Form/Format

QKI protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT.
Sterile Filtered clear solution.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Molecular Weight

35,131 Da

OMIM

609590

3D Structure

ModBase 3D Structure for Q96PU8

Product Categories/Family for QKI recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of QKI recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for QKI purchase

MBS144865 is a recombinant protein targeting QKI. Also known as Recombinant Human QKI. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for QKI. It may not necessarily be applicable to this product.

NCBI GI #

666637982

NCBI GeneID

9444

NCBI Accession #

NP_001288014.1

UniProt Primary Accession #

Q96PU8

UniProt Secondary Accession #

Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9

UniProt Related Accession #

Q96PU8

GenBank Nucleotide #

NM_001301085.1

NCBI Official Full Name

protein quaking isoform 5

NCBI Official Synonym Full Names

QKI, KH domain containing, RNA binding

NCBI Official Symbol

QKI

NCBI Official Synonym Symbols

QK; Hqk; QK1; QK3; hqkI

UniProt Protein Name

Protein quaking

Protein Family

Protein quaking

UniProt Gene Name

QKI

UniProt Synonym Gene Names

HKQ; Hqk; HqkI

UniProt Entry Name

QKI_HUMAN

NCBI Protein Information

protein quaking; RNA binding protein HQK; homolog of mouse quaking QKI (KH domain RNA binding protein); quaking homolog, KH domain RNA binding

NCBI Summary for QKI

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

UniProt Comments for QKI

QKI: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. 6 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cytoplasm; nucleus

Molecular Function: mRNA binding; protein binding; SH3 domain binding

Biological Process: regulation of translation; myelination; muscle cell differentiation; mRNA transport; RNA splicing; long-chain fatty acid biosynthetic process; vasculogenesis; mRNA processing; spermatid development

Research Articles on QKI

1. QKI as a key regulator of alternative splicing in lung cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with QKI recombinant protein

Products by Pathway	Pathway Diagram
Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies	Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram

Diseases associated with QKI recombinant protein

Disease Name	Pubmed Publications
Glioblastoma Antibodies	>7 publications with QKI and Glioblastoma
Disease Models, Animal Antibodies	>5 publications with QKI and Disease Models, Animal
Carcinoma, Hepatocellular Antibodies	>3 publications with QKI and Carcinoma, Hepatocellular
Breast Neoplasms Antibodies	>3 publications with QKI and Breast Neoplasms
Ovarian Neoplasms Antibodies	>3 publications with QKI and Ovarian Neoplasms
Liver Diseases Antibodies	>2 publications with QKI and Liver Diseases
Abnormalities, Multiple Antibodies	>2 publications with QKI and Abnormalities, Multiple
Adenocarcinoma Antibodies	>2 publications with QKI and Adenocarcinoma
Lung Neoplasms Antibodies	>2 publications with QKI and Lung Neoplasms
Hyperplasia Antibodies	>2 publications with QKI and Hyperplasia

Organs/Tissues associated with QKI recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>38 publications with QKI and Brain
Nerve Antibodies	>27 publications with QKI and Nerve
Embryonic Tissue Antibodies	>10 publications with QKI and Embryonic Tissue
Blood Antibodies	>8 publications with QKI and Blood
Heart Antibodies	>7 publications with QKI and Heart
Vascular Antibodies	>7 publications with QKI and Vascular
Muscle Antibodies	>6 publications with QKI and Muscle
Lung Antibodies	>3 publications with QKI and Lung
Kidney Antibodies	>2 publications with QKI and Kidney
Liver Antibodies	>2 publications with QKI and Liver