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Gamma-Glutamyl Hydrolase (GGH) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144869

Description: GGH Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (25-318) and having a molecular mass of 35.9kDa.GGH is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gamma-Glutamyl Hydrolase (GGH), Recombinant Protein
Full Product Name
Recombinant Human Gamma-Glutamyl Hydrolase
Product Gene Name
GGH recombinant protein
Product Synonym Names
GGH Human; Gamma-Glutamyl Hydrolase Human Recombinant; Gamma-glutamyl hydrolase (conjugase; folylpolygammaglutamyl hydrolase); Gamma-Glu-X carboxypeptidase; gamma-glutamyl hydrolase; Conjugase; GH; EC 3.4.19.9
Sequence
MGSSHHH HHH SSGLVPRGSH MRPHGD TAKK PIIGILMQKC RNKVMKNYGR YYIAASYVKY LESAGARVVP VRLDLTEKDY EILFKSINGI LFPGGSVDLR RSDYAKVAKI FYNLSIQSFD DGDYFPVWGT CLGFEELSLL ISGECLLTAT DTVDVAMPLN FTGGQLHSRM FQNFPTELLL SLAVEPLTAN FHKWSLSVKN FTMNEKLKKF FNVLTTNTDG KIEFISTMEG YKYPVYGVQW HPEKAPYEWK NLDGISHAPN AVKTAFYLAE FFVNEARKNN HHFKSESEEE KALIYQFSPI YTGNISSFQQ CYIFD
Host
E Coli
Form/Format
The GGH solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 10% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Molecular Weight
35,964 Da
OMIM
601509
3D Structure
ModBase 3D Structure for Q92820

Product Categories/Family for GGH recombinant protein

Enzymes; Hydrolase

Other Notes

Small volumes of GGH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GGH purchase

MBS144869 is a recombinant protein targeting GGH. Also known as Recombinant Human Gamma-Glutamyl Hydrolase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GGH. It may not necessarily be applicable to this product.

NCBI GI #
4503987
NCBI GeneID
8836
NCBI Accession #
NP_003869.1
UniProt Primary Accession #
Q92820
UniProt Related Accession #
Q92820
GenBank Nucleotide #
NM_003878.2
NCBI Official Full Name
gamma-glutamyl hydrolase
NCBI Official Synonym Full Names
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
NCBI Official Symbol
GGH
NCBI Official Synonym Symbols
GH
UniProt Protein Name
Gamma-glutamyl hydrolase
UniProt Synonym Protein Names
Conjugase; GH; Gamma-Glu-X carboxypeptidase
Protein Family
Gamma-glutamyl hydrolase
UniProt Gene Name
GGH
UniProt Entry Name
GGH_HUMAN
NCBI Protein Information
gamma-glutamyl hydrolase; gamma-Glu-X carboxypeptidase

NCBI Summary for GGH

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

UniProt Comments for GGH

GGH: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Belongs to the peptidase C26 family.

Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; Protease; EC 3.4.19.9; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q12.3

Cellular Component: extracellular space; lysosome; melanosome; nucleus; cytosol

Molecular Function: omega peptidase activity; exopeptidase activity

Biological Process: response to drug; response to ethanol; response to zinc ion; glutamine metabolic process; proteolysis; response to insulin stimulus
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Research Articles on GGH

1. Polymorphism of GGH rs3758149 C>T is associated with response to therapy in acute lymphoblastic leukemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GGH recombinant protein

 Reference Product  PubMed Publications
 FPGS recombinant protein  >29 publications with GGH and FPGS
 DHFR recombinant protein  >9 publications with GGH and DHFR
 GSTP1 recombinant protein  >2 publications with GGH and GSTP1
 GSTA4 recombinant protein  >1 publications with GGH and GSTA4

Pathways associated with GGH recombinant protein

 Products by Pathway  Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Glutamate Removal From Folates Pathway antibodies  Glutamate Removal From Folates Pathway Diagram
 Glutathione-mediated Detoxification Pathway antibodies  Glutathione-mediated Detoxification Pathway Diagram

Diseases associated with GGH recombinant protein

 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >10 publications with GGH and Colorectal Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with GGH and Neoplasms, Experimental
 Liver Diseases Antibodies  >8 publications with GGH and Liver Diseases
 Adenocarcinoma Antibodies  >7 publications with GGH and Adenocarcinoma
 Hepatitis Antibodies  >7 publications with GGH and Hepatitis
 Inflammation Antibodies  >5 publications with GGH and Inflammation
 Carcinoma, Hepatocellular Antibodies  >5 publications with GGH and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >4 publications with GGH and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >4 publications with GGH and Breast Neoplasms
 Liver Neoplasms Antibodies  >3 publications with GGH and Liver Neoplasms

Organs/Tissues associated with GGH recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with GGH and Blood
 Liver Antibodies  >15 publications with GGH and Liver
 Intestine Antibodies  >11 publications with GGH and Intestine
 Lung Antibodies  >10 publications with GGH and Lung
 Bone Antibodies  >8 publications with GGH and Bone
 Brain Antibodies  >8 publications with GGH and Brain
 Vascular Antibodies  >3 publications with GGH and Vascular
 Lymph Node Antibodies  >3 publications with GGH and Lymph Node
 Connective Tissue Antibodies  >3 publications with GGH and Connective Tissue
 Bone Marrow Antibodies  >3 publications with GGH and Bone Marrow
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