Human NUDT3 Recombinant Protein – Cat# MBS144879

Nudix Type Motif 3 (NUDT3) Human Recombinant Protein

Name: NUDT3 Recombinant Protein; Nudix Type Motif 3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144879
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144879

Description: NUDT3 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular mass of 21.6kDa. The NUDT3 is purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nudix Type Motif 3 (NUDT3), Recombinant Protein

Full Product Name

Recombinant Human Nudix Type Motif 3

Product Gene Name

NUDT3 recombinant protein

Product Synonym Names

NUDT3 Human; Nudix Type Motif 3 Human Recombinant; Diphosphoinositol polyphosphate phosphohydrolase 1; DIPP-1; Diadenosine 5'; 5'''-P1; P6-hexaphosphate hydrolase 1; Nucleoside diphosphate-linked moiety X motif 3; Nudix motif 3; NUDT3; DIPP; DIPP1

Sequence

MGSSHHH HHH SSGLVPRGSH MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR

Host

E Coli

Form/Format

The NUDT3 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Molecular Weight

19,471 Da

OMIM

609228

3D Structure

ModBase 3D Structure for O95989

Product Categories/Family for NUDT3 recombinant protein

Enzymes; Nudix Type Motif

Other Notes

Small volumes of NUDT3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NUDT3 purchase

MBS144879 is a recombinant protein targeting NUDT3. Also known as Recombinant Human Nudix Type Motif 3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NUDT3. It may not necessarily be applicable to this product.

NCBI GI #

5729804

NCBI GeneID

11165

NCBI Accession #

NP_006694.1

UniProt Primary Accession #

O95989

UniProt Secondary Accession #

B2R8N4

UniProt Related Accession #

O95989

GenBank Nucleotide #

NM_006703.3

NCBI Official Full Name

diphosphoinositol polyphosphate phosphohydrolase 1

NCBI Official Synonym Full Names

nudix (nucleoside diphosphate linked moiety X)-type motif 3

NCBI Official Symbol

NUDT3

NCBI Official Synonym Symbols

DIPP; DIPP1; DIPP-1

UniProt Protein Name

Diphosphoinositol polyphosphate phosphohydrolase 1

UniProt Synonym Protein Names

Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1 (EC:3.6.1.-); Nucleoside diphosphate-linked moiety X motif 3; Nudix motif 3

Protein Family

Diphosphoinositol polyphosphate phosphohydrolase

UniProt Gene Name

NUDT3

UniProt Synonym Gene Names

DIPP; DIPP1; DIPP-1; Nudix motif 3

UniProt Entry Name

NUDT3_HUMAN

NCBI Protein Information

diphosphoinositol polyphosphate phosphohydrolase 1; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; nucleoside diphosphate-linked moiety X motif 3; nudix motif 3

NCBI Summary for NUDT3

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

UniProt Comments for NUDT3

NUDT3: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate. Belongs to the Nudix hydrolase family. DIPP subfamily.

Protein type: Hydrolase; EC 3.6.1.52

Chromosomal Location of Human Ortholog: 6p21.2

Cellular Component: cytosol

Molecular Function: magnesium ion binding; diphosphoinositol-polyphosphate diphosphatase activity

Biological Process: inositol phosphate metabolic process; cell-cell signaling; diadenosine polyphosphate catabolic process

Research Articles on NUDT3

1. results suggest that NUDT3 rs206936 is associated with body mass index in Japanese women

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NUDT3 recombinant protein

Reference Product	PubMed Publications
NUDT2 recombinant protein	>1 publications with NUDT3 and NUDT2

Pathways associated with NUDT3 recombinant protein

Products by Pathway	Pathway Diagram
Inositol Phosphate Metabolism Pathway antibodies	Inositol Phosphate Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Synthesis Of Pyrophosphates In The Cytosol Pathway antibodies	Synthesis Of Pyrophosphates In The Cytosol Pathway Diagram

Diseases associated with NUDT3 recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>1 publications with NUDT3 and Liver Diseases

Organs/Tissues associated with NUDT3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>1 publications with NUDT3 and Connective Tissue
Bone Antibodies	>1 publications with NUDT3 and Bone
Blood Antibodies	>1 publications with NUDT3 and Blood