Human IDI1 Recombinant Protein – Cat# MBS144895

Isopentenyl-Diphosphate Delta Isomerase 1 (IDI1) Human Recombinant Protein

Name: IDI1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144895
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144895

Description: IDI1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 248 amino acids (1-228) and having a molecular mass of 28.6kDa.IDI1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Isopentenyl-Diphosphate Delta Isomerase 1 (IDI1), Recombinant Protein

Full Product Name

Recombinant Human Isopentenyl-Diphosphate Delta Isomerase 1

Product Gene Name

IDI1 recombinant protein

Product Synonym Names

IDI1 Human; Isopentenyl-Diphosphate Delta Isomerase 1 Human Recombinant; Isopentenyl-diphosphate Delta-isomerase 1; Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1; IDI1; IPP1

Sequence

MGSSHHH HHH SSGLVPRGSH MMPEINTNHL DKQQVQLLAE MCILIDENDN KIGAETKKNC HLNENIEKGL LHRAFSVFLF NTENKLLLQQ RSDAKITFPG CFTNTCCSHP LSNPAELEES DALGVRRAAQ RRLKAELGIP LEEVPPEEIN YLTRIHYKAQ SDGIWGEHEI DYILLVRKNV TLNPDPNEIK SYCYVSKEEL KELLKKAASG EIKITPWFKI IAATFLFKWW DNLNHLNQFV DHEKIYRM.< /u>

Host

E Coli

Form/Format

The IDI1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Molecular Weight

32,485 Da

OMIM

604055

3D Structure

ModBase 3D Structure for Q13907

Product Categories/Family for IDI1 recombinant protein

Enzymes; Isomerase

Other Notes

Small volumes of IDI1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IDI1 purchase

MBS144895 is a recombinant protein targeting IDI1. Also known as Recombinant Human Isopentenyl-Diphosphate Delta Isomerase 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IDI1. It may not necessarily be applicable to this product.

NCBI GI #

40018633

NCBI GeneID

3422

NCBI Accession #

NP_004499.2

UniProt Primary Accession #

Q13907

UniProt Secondary Accession #

Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74; B4E155

UniProt Related Accession #

Q13907

GenBank Nucleotide #

NM_004508.2

NCBI Official Full Name

isopentenyl-diphosphate Delta-isomerase 1

NCBI Official Synonym Full Names

isopentenyl-diphosphate delta isomerase 1

NCBI Official Symbol

IDI1

NCBI Official Synonym Symbols

IPP1; IPPI1

UniProt Protein Name

Isopentenyl-diphosphate Delta-isomerase 1

UniProt Synonym Protein Names

Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1

Protein Family

Isopentenyl-diphosphate Delta-isomerase

UniProt Gene Name

IDI1

UniProt Synonym Gene Names

IPP isomerase 1; IPPI1

UniProt Entry Name

IDI1_HUMAN

NCBI Protein Information

isopentenyl-diphosphate Delta-isomerase 1; IPP isomerase 1; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; isopentenyl pyrophosphate isomerase 1

NCBI Summary for IDI1

IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

UniProt Comments for IDI1

IDI1: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Belongs to the IPP isomerase type 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Isomerase; EC 5.3.3.2

Chromosomal Location of Human Ortholog: 10p15.3

Cellular Component: mitochondrion; peroxisome; cytosol

Molecular Function: hydrolase activity; metal ion binding; manganese ion binding; magnesium ion binding; isopentenyl-diphosphate delta-isomerase activity

Biological Process: isoprenoid biosynthetic process; dimethylallyl diphosphate biosynthetic process; cholesterol biosynthetic process

Research Articles on IDI1

1. Within the 40-kb region on 10p15.3 subtelomere, which harbours two genes encoding isopentenyl diphosphate isomerase 1 (IDI1) and IDI2, there was found a segmental copy-number gain in a large proportion of sporadic amyotrophic lateral sclerosis patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IDI1 recombinant protein

Reference Product	PubMed Publications
FDPS recombinant protein	>6 publications with IDI1 and FDPS
IDI2 recombinant protein	>4 publications with IDI1 and IDI2
MVD recombinant protein	>4 publications with IDI1 and MVD
SQLE recombinant protein	>3 publications with IDI1 and SQLE
CYP51A1 recombinant protein	>2 publications with IDI1 and CYP51A1

Pathways associated with IDI1 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies	Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies	C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies	C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
Cholesterol Biosynthesis Pathway antibodies	Cholesterol Biosynthesis Pathway Diagram
Cholesterol Biosynthesis Pathway antibodies	Cholesterol Biosynthesis Pathway Diagram
Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies	Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway antibodies	Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway Diagram

Diseases associated with IDI1 recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>3 publications with IDI1 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>2 publications with IDI1 and Nervous System Diseases
Brain Diseases Antibodies	>1 publications with IDI1 and Brain Diseases
Breast Neoplasms Antibodies	>1 publications with IDI1 and Breast Neoplasms
Hypertension Antibodies	>1 publications with IDI1 and Hypertension
Fatty Liver Antibodies	>1 publications with IDI1 and Fatty Liver
Inflammation Antibodies	>1 publications with IDI1 and Inflammation
Hyperplasia Antibodies	>1 publications with IDI1 and Hyperplasia

Organs/Tissues associated with IDI1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4 publications with IDI1 and Blood
Muscle Antibodies	>3 publications with IDI1 and Muscle
Liver Antibodies	>3 publications with IDI1 and Liver
Testis Antibodies	>2 publications with IDI1 and Testis
Pancreas Antibodies	>1 publications with IDI1 and Pancreas
Heart Antibodies	>1 publications with IDI1 and Heart
Bone Marrow Antibodies	>1 publications with IDI1 and Bone Marrow
Bone Antibodies	>1 publications with IDI1 and Bone
Lung Antibodies	>1 publications with IDI1 and Lung
Brain Antibodies	>1 publications with IDI1 and Brain