Cleavage Stimulation Factor 1 (CSTF1) Human Recombinant Protein

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

CSTF1: one of three subunits of cleavage stimulation factor (CSTF), a polyadenylation factor that cleaves the 3a??a??end of pre-mRNAs. Binds to the C-terminal ankyrin and tandem BRCT repeat domains of BARD1 (BRCA1-associated RING domain protein), modulating mRNA processing and RNAP II stability in response to DNA damage. The BARD1-CstF-50 interaction inhibits polyadenylation in vitro. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. WD domains are responsible for interaction with CSTF3. The sixth WD40 domain is required for interaction with BARD1.

Protein type: RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: protein binding; RNA binding

Biological Process: RNA processing; transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA polyadenylation; mRNA 3'-end processing; termination of RNA polymerase II transcription; mRNA cleavage