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DNA Damage Inducible Transcript 4 (DDIT4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144906

Description: DDIT4 produced in E Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-232.a.a) and having a molecular mass of 27.5kDa. DDIT4 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNA Damage Inducible Transcript 4 (DDIT4), Recombinant Protein
Full Product Name
Recombinant Human DNA Damage Inducible Transcript 4
Product Gene Name
DDIT4 recombinant protein
Product Synonym Names
DDIT4 Human; DNA Damage Inducible Transcript 4 Recombinant Human; DNA-damage-inducible transcript 4; RTP801; REDD-1; Dig2; FLJ20500; Protein regulated in development and DNA damage response 1; HIF-1 responsive protein RTP801; RP11-442H21.1
Sequence
MGSSHHH HHH SSGLVPRGSH MPSLWDRFSS SSTSSSPSSL PRTPTPDRPP RSAWGSATRE EGFDRSTSLE SSDCESLDSS NSGFGPEEDT AYLDGVSLPD FELLSDPEDE HLCANLMQLL QESLAQARLG SRRPARLLMP SQLVSQVGKE LLRLAYSEPC GLRGALLDVC VEQGKSCHSV GQLALDPSLV PTFQLTLVLR LDSRLWPKIQ GLFSSANSPF LPGFSQSLTL STGFRVIKKK LYSSEQLLIE EC
Host
E Coli
Form/Format
The DDIT4 protein solution (0.25mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT, 1mM EDTA and 30% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Molecular Weight
25,371 Da
OMIM
607729
3D Structure
ModBase 3D Structure for Q9NX09

Product Categories/Family for DDIT4 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; DNA-Damage Protein

Other Notes

Small volumes of DDIT4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DDIT4 purchase

MBS144906 is a recombinant protein targeting DDIT4. Also known as Recombinant Human DNA Damage Inducible Transcript 4. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DDIT4. It may not necessarily be applicable to this product.

NCBI GI #
9506687
NCBI GeneID
54541
NCBI Accession #
NP_061931.1
UniProt Primary Accession #
Q9NX09
UniProt Secondary Accession #
Q9H0S3
UniProt Related Accession #
Q9NX09
GenBank Nucleotide #
NM_019058.2
NCBI Official Full Name
DNA damage-inducible transcript 4 protein
NCBI Official Synonym Full Names
DNA-damage-inducible transcript 4
NCBI Official Symbol
DDIT4
NCBI Official Synonym Symbols
Dig2; REDD1; REDD-1
UniProt Protein Name
DNA damage-inducible transcript 4 protein
UniProt Synonym Protein Names
HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1
Protein Family
DNA damage-inducible transcript 4 protein
UniProt Gene Name
DDIT4
UniProt Synonym Gene Names
REDD1; RTP801; REDD-1
UniProt Entry Name
DDIT4_HUMAN
NCBI Protein Information
DNA damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; protein regulated in development and DNA damage response 1

UniProt Comments for DDIT4

DDIT4: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family.

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: mitochondrion; cytoplasm; intracellular; cytosol

Biological Process: neuron differentiation; cell proliferation; negative regulation of TOR signaling pathway; protein complex disassembly; nerve growth factor receptor signaling pathway; neuron migration; response to hypoxia; negative regulation of peptidyl-serine phosphorylation; brain development; negative regulation of glycolysis; defense response to virus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
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Research Articles on DDIT4

1. analysis of ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DDIT4 recombinant protein

 Reference Product  PubMed Publications
 MTOR recombinant protein  >72 publications with DDIT4 and MTOR
 TSC2 recombinant protein  >20 publications with DDIT4 and TSC2
 TSC1 recombinant protein  >15 publications with DDIT4 and TSC1
 TP53 recombinant protein  >3 publications with DDIT4 and TP53

Pathways associated with DDIT4 recombinant protein

 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 TOR Signaling Pathway antibodies  TOR Signaling Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram

Diseases associated with DDIT4 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with DDIT4 and Nervous System Diseases
 Disease Models, Animal Antibodies  >10 publications with DDIT4 and Disease Models, Animal
 Breast Neoplasms Antibodies  >9 publications with DDIT4 and Breast Neoplasms
 Brain Diseases Antibodies  >8 publications with DDIT4 and Brain Diseases
 Leukemia Antibodies  >7 publications with DDIT4 and Leukemia
 Cardiovascular Diseases Antibodies  >6 publications with DDIT4 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >5 publications with DDIT4 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >4 publications with DDIT4 and Inflammation
 Lung Neoplasms Antibodies  >4 publications with DDIT4 and Lung Neoplasms
 Liver Diseases Antibodies  >4 publications with DDIT4 and Liver Diseases

Organs/Tissues associated with DDIT4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >20 publications with DDIT4 and Muscle
 Blood Antibodies  >18 publications with DDIT4 and Blood
 Liver Antibodies  >13 publications with DDIT4 and Liver
 Brain Antibodies  >12 publications with DDIT4 and Brain
 Lung Antibodies  >7 publications with DDIT4 and Lung
 Prostate Antibodies  >6 publications with DDIT4 and Prostate
 Bone Antibodies  >5 publications with DDIT4 and Bone
 Nerve Antibodies  >5 publications with DDIT4 and Nerve
 Vascular Antibodies  >4 publications with DDIT4 and Vascular
 Heart Antibodies  >3 publications with DDIT4 and Heart
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