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Dehydrogenase/Reductase Member 9 (DHRS9) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144908

Description: DHRS9 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 327 amino acids (18-319) and having a molecular mass of 35.9kDa.DHRS9 is fused to a 21 amino acid His-tag at N-terminus & purified by… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Dehydrogenase/Reductase Member 9 (DHRS9), Recombinant Protein
Full Product Name
Recombinant Human Dehydrogenase/Reductase Member 9
Product Gene Name
DHRS9 recombinant protein
Product Synonym Names
DHRS9 Human; Dehydrogenase/Reductase Member 9 Human Recombinant; Dehydrogenase/reductase SDR family member 9; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; NADP-dependent retinol dehydrogenase/reductase; RDH-E2; RDHL; Short-chain dehydrogenase/reductase retSDR8; DHRS9; RDH15; RDHTBE; SDR9C4; RETSDR8; 3ALPHA-HSD
Sequence
MGSSHHH HHH SSGLVPRGSH MGSHMR KGKL KIEDITDKYI FITGCDSGFG NLAARTFDKK GFHVIAACLT ESGSTALKAE TSERLRTVLL DVTDPENVKR TAQWVKNQVG EKGLWGLINN AGVPGVLAPT DWLTLEDYRE PIEVNLFGLI SVTLNMLPLV KKAQGRVINV SSVGGRLAIV GGGYTPSKYA VEGFNDSLRR DMKAFGVHVS CIEPGLFKTN LADPVKVIEK KLAIWEQLSP DIKQQYGEGY IEKSLDKLKG NKSYVNMDLS PVVECMDHAL TSLFPKTHYA AGKDAKIFWI PLSHMPAALQ DFLLLKQKAE LANPKAV.
Host
E Coli
Form/Format
The DHRS9 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl, 1mM DTT and 0.1mM PMSF.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
41,927 Da
OMIM
612131
3D Structure
ModBase 3D Structure for Q9BPW9

Product Categories/Family for DHRS9 recombinant protein

Enzymes; Reductase

Other Notes

Small volumes of DHRS9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DHRS9 purchase

MBS144908 is a recombinant protein targeting DHRS9. Also known as Recombinant Human Dehydrogenase/Reductase Member 9. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DHRS9. It may not necessarily be applicable to this product.

NCBI GI #
214010156
NCBI GeneID
10170
NCBI Accession #
NP_001135742.1
UniProt Primary Accession #
Q9BPW9
UniProt Secondary Accession #
Q5RKX1; Q9NRA9; Q9NRB0; B7Z416; D3DPC1
UniProt Related Accession #
Q9BPW9
GenBank Nucleotide #
NM_001142270.1
NCBI Official Full Name
dehydrogenase/reductase SDR family member 9 isoform 1
NCBI Official Synonym Full Names
dehydrogenase/reductase (SDR family) member 9
NCBI Official Symbol
DHRS9
NCBI Official Synonym Symbols
RDHL; RDH15; RDH-E2; RDHTBE; SDR9C4; RDH-TBE; RETSDR8; 3ALPHA-HSD; 3-alpha-HSD
UniProt Protein Name
Dehydrogenase/reductase SDR family member 9
UniProt Synonym Protein Names
3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; NADP-dependent retinol dehydrogenase/reductase; RDH-E2; RDHL; Short-chain dehydrogenase/reductase retSDR8; Tracheobronchial epithelial cell-specific retinol dehydrogenase; RDH-TBE
Protein Family
Dehydrogenase/reductase SDR family
UniProt Gene Name
DHRS9
UniProt Synonym Gene Names
3-alpha-HSD; RDH-TBE
UniProt Entry Name
DHRS9_HUMAN
NCBI Protein Information
dehydrogenase/reductase SDR family member 9; 3-alpha hydroxysteroid dehydrogenase; NADP-dependent retinol dehydrogenase/reductase; retinol dehydrogenase homolog; short chain dehydrogenase/reductase family 9C, member 4; short-chain dehydrogenase/reductase retSDR8; tracheobronchial epithelial cell-specific retinol dehydrogenase

NCBI Summary for DHRS9

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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UniProt Comments for DHRS9

DHRS9: 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Endoplasmic reticulum; Secreted, signal peptide; EC 1.1.-.-

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane

Molecular Function: alcohol dehydrogenase activity; racemase and epimerase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; retinol dehydrogenase activity

Biological Process: epithelial cell differentiation; retinol metabolic process; androgen metabolic process; 9-cis-retinoic acid biosynthetic process; progesterone metabolic process
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Research Articles on DHRS9

1. Dehydrogenase/reductase SDR family member 9 is a moonlighting protein that functions as both a metabolic enzyme and as a transcriptional repressor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DHRS9 recombinant protein

 Reference Product  PubMed Publications
 CYP26A1 recombinant protein  >3 publications with DHRS9 and CYP26A1
 MN1 recombinant protein  >1 publications with DHRS9 and MN1
 ALDH1A1 recombinant protein  >1 publications with DHRS9 and ALDH1A1
 ALDH1A2 recombinant protein  >1 publications with DHRS9 and ALDH1A2

Pathways associated with DHRS9 recombinant protein

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 RA Biosynthesis Pathway antibodies  RA Biosynthesis Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Retinoic Acid Pathway antibodies  Signaling By Retinoic Acid Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram

Diseases associated with DHRS9 recombinant protein

 Disease Name  Pubmed Publications
 Leukemia, Myeloid Antibodies  >1 publications with DHRS9 and Leukemia, Myeloid
 Disease Models, Animal Antibodies  >1 publications with DHRS9 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with DHRS9 and Kidney Diseases
 Inflammation Antibodies  >1 publications with DHRS9 and Inflammation
 Fibrosis Antibodies  >1 publications with DHRS9 and Fibrosis
 Neoplasms, Experimental Antibodies  >1 publications with DHRS9 and Neoplasms, Experimental

Organs/Tissues associated with DHRS9 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >3 publications with DHRS9 and Skin
 Connective Tissue Antibodies  >2 publications with DHRS9 and Connective Tissue
 Intestine Antibodies  >2 publications with DHRS9 and Intestine
 Testis Antibodies  >1 publications with DHRS9 and Testis
 Ovary Antibodies  >1 publications with DHRS9 and Ovary
 Trachea Antibodies  >1 publications with DHRS9 and Trachea
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