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GRO-Gamma (mGRO g) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144927

Description: GRO-g Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 98 amino acids (28-100 a.a.) and having a molecular mass of 10.6kDa.CXCL3 is fused to a 25 amino acid His-tag at N-terminus & purified by… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GRO-gamma (mGRO g), Recombinant Protein
Full Product Name
Recombinant Mouse GRO-gamma (CXCL3), His Tag
Product Gene Name
mGRO g recombinant protein
Product Synonym Names
GRO g Mouse, His; GRO-Gamma Mouse Recombinant (CXCL3), His Tag; C-X-C motif chemokine 3; Dendritic cell inflammatory protein 1; Cxcl3; Dcip1; Gm1960; GRO-g; mGRO g His
Sequence
MGSSHHH HHH SSGLVPRGSH MGSHMA VVAS ELRCQCLNTL PRVDFETIQS LTVTPPGPHC TQTEVIATLK DGQEVCLNPQ GPRLQIIIKK ILKSGKSS
Host
E Coli
Form/Format
GRO-gamma protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 50% glycerol, 0.15M NaCl and 5mM DTT.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
10,686 Da
3D Structure
ModBase 3D Structure for Q6W5C0

Product Categories/Family for mGRO g recombinant protein

Chemokines; GRO

Other Notes

Small volumes of mGRO g recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mGRO g purchase

MBS144927 is a recombinant protein targeting mGRO g. Also known as Recombinant Mouse GRO-gamma (CXCL3), His Tag. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mGRO g. It may not necessarily be applicable to this product.

NCBI GI #
42600573
NCBI GeneID
330122
NCBI Accession #
NP_976065.1
UniProt Primary Accession #
Q6W5C0
UniProt Secondary Accession #
Q3UNK9
UniProt Related Accession #
Q6W5C0
GenBank Nucleotide #
NM_203320.3
NCBI Official Full Name
C-X-C motif chemokine 3
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 3
NCBI Official Symbol
Cxcl3
NCBI Official Synonym Symbols
Dcip1; Gm1960
UniProt Protein Name
C-X-C motif chemokine 3
UniProt Synonym Protein Names
Dendritic cell inflammatory protein 1
Protein Family
Growth-regulated protein
UniProt Gene Name
Cxcl3
UniProt Entry Name
CXCL3_MOUSE
NCBI Protein Information
C-X-C motif chemokine 3; cxcl3; dendritic cell inflammatory protein 1

NCBI Summary for mGRO g

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013]
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UniProt Comments for mGRO g

CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; chemotaxis; inflammatory response; regulation of cell proliferation
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Research Articles on mGRO g

1. Tis21 induces migration of cerebellar granule neuron precursor cells through Cxcl3, which may represent a novel target for medulloblastoma therapy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mGRO g recombinant protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with mGRO g recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >73 publications with mGRO g and Inflammation
 Necrosis Antibodies  >35 publications with mGRO g and Necrosis
 Respiratory Tract Diseases Antibodies  >13 publications with mGRO g and Respiratory Tract Diseases
 Lung Diseases Antibodies  >13 publications with mGRO g and Lung Diseases
 Immune System Diseases Antibodies  >11 publications with mGRO g and Immune System Diseases
 Skin Diseases Antibodies  >9 publications with mGRO g and Skin Diseases
 Disease Models, Animal Antibodies  >7 publications with mGRO g and Disease Models, Animal
 Death Antibodies  >7 publications with mGRO g and Death
 Fibrosis Antibodies  >6 publications with mGRO g and Fibrosis
 Neoplasms, Experimental Antibodies  >4 publications with mGRO g and Neoplasms, Experimental

Organs/Tissues associated with mGRO g recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >64 publications with mGRO g and Blood
 Lung Antibodies  >18 publications with mGRO g and Lung
 Skin Antibodies  >9 publications with mGRO g and Skin
 Bone Marrow Antibodies  >7 publications with mGRO g and Bone Marrow
 Mammary Gland Antibodies  >6 publications with mGRO g and Mammary Gland
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