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Regulator of Telomere Elongation Helicase 1 (RTEL1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1449337

In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability… More details

$1365 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Regulator of telomere elongation helicase 1 (RTEL1), Recombinant Protein
Full Product Name
Recombinant Human Regulator of telomere elongation helicase 1 (RTEL1) , partial
Product Gene Name
RTEL1 recombinant protein
Product Synonym Gene Name
RTEL1
Sequence
MPAPAPRATA PSVRGEDAVS EAKSPGPFFS TRKAKSLDLH VPSLKQRSSG SPAAGDPESS LCVEYEQEPV PARQRPRGLL AALEHSEQRA GSPGEEQAHS CSTLSLLSEK RPAEEPRGGR KKIRLVSHPE EPVAGAQTDR AKLFMVAVKQ ELSQANFATF TQALQDYKGS DDFAALAACL GPLFAEDPKK HNLLQGFYQF VRPHHKQQFE EVCIQLTGRG CGYRPEHSIP RRQRAQPVLD PTGRTAPDPK LTVSTAAAQQ LDPQEHLNQG RPHLSPRPPP TGDPGSQPQW GSGVPRAGKQ GQHAVSAYLA DARRALGSAG CSQLLAALTA YKQDDDLDKV LAVLAALTTA KPEDFPLLHR FSMFVRPHHK QRFSQTCTDL TGRPYPGMEP PGPQEERLAV PPVLTHRAPQ PGPSRSEKTG KTQSKISSFL RQRPAGTVGA GGEDAGPSQS SGPPHGPAAS EWGEPHGRDI AGQQATGAPG GPLSAGCVCQ GCGAEDVVPF QCPACDFQRC QACWQRHLQA SRMCPACHTA SRKQSVMQVF WPEPQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
108,457 Da
Sequence Positions
1-545. Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
608833
3D Structure
ModBase 3D Structure for Q9NZ71
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RTEL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RTEL1 purchase

MBS1449337 is a recombinant protein targeting RTEL1. Also known as Recombinant Human Regulator of telomere elongation helicase 1 (RTEL1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RTEL1. It may not necessarily be applicable to this product.

NCBI GI #
545688900
NCBI GeneID
51750
NCBI Accession #
NP_001269938.1
UniProt Primary Accession #
Q9NZ71
UniProt Secondary Accession #
Q5JTV3; Q5JTV4; Q9BW37; Q9H402; A2A397; A2A398; B4DRM5; B4DYM3; B4E3N6; E1P5J4; E1P5J5
UniProt Related Accession #
Q9NZ71
GenBank Nucleotide #
NM_001283009.1
NCBI Official Full Name
regulator of telomere elongation helicase 1 isoform 3
NCBI Official Synonym Full Names
regulator of telomere elongation helicase 1
NCBI Official Symbol
RTEL1
NCBI Official Synonym Symbols
NHL; RTEL; DKCA4; DKCB5; PFBMFT3; C20orf41
UniProt Protein Name
Regulator of telomere elongation helicase 1
UniProt Synonym Protein Names
Novel helicase-like
Protein Family
Regulator of telomere elongation helicase
UniProt Gene Name
RTEL1
NCBI Protein Information
regulator of telomere elongation helicase 1

NCBI Summary for RTEL1

This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
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UniProt Comments for RTEL1

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
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Research Articles on RTEL1

1. Findings suggest a potential association between regulator of telomere elongation helicase 1 (RTEL1) polymorphisms and lung cancer (LC) risk in a Chinese Han population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RTEL1 recombinant protein

 Products by Pathway  Pathway Diagram
 Cytosolic Iron-sulfur Cluster Assembly Pathway antibodies  Cytosolic Iron-sulfur Cluster Assembly Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with RTEL1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >16 publications with RTEL1 and Neoplasms
 Glioma Antibodies  >15 publications with RTEL1 and Glioma
 Neoplasms, Experimental Antibodies  >2 publications with RTEL1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with RTEL1 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with RTEL1 and Lung Diseases
 Carcinoma Antibodies  >1 publications with RTEL1 and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with RTEL1 and Breast Neoplasms
 Melanoma Antibodies  >1 publications with RTEL1 and Melanoma
 Ovarian Neoplasms Antibodies  >1 publications with RTEL1 and Ovarian Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with RTEL1 and Carcinoma, Hepatocellular

Organs/Tissues associated with RTEL1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with RTEL1 and Brain
 Nerve Antibodies  >2 publications with RTEL1 and Nerve
 Liver Antibodies  >1 publications with RTEL1 and Liver
 Blood Antibodies  >1 publications with RTEL1 and Blood
 Lung Antibodies  >1 publications with RTEL1 and Lung
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