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Ubiquitin Carboxyl-Terminal Hydrolase 14 (USP14) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1449959

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused… More details

$1290 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ubiquitin carboxyl-terminal hydrolase 14 (Usp14), Recombinant Protein
Full Product Name
Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 14 (Usp14)
Product Gene Name
Usp14 recombinant protein
Product Synonym Gene Name
Usp14
Sequence
MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN IKMKNGMTVL MMGSADALPE EPSAKTVFVE DMTEEQLATA MELPCGLTNL GNTCYMNATV QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH MAFPQFAEKG EQGQYLQQDA NECWIQMMRV LQQKLEAIED DSGRETDSSS APAVTPSKKK SLIDQYFGVE FETTMKCTES EEEEVTKGKE NQLQLSCFIN QEVKYLFTGL KLRLQEEITK QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDVYELCT PELQEKMVSF RSKFKDLEDK KVNQQPNAND KNSPPKEIKY EPFSFADDIG SNNCGYYDLQ AVLTHQGRSS SSGHYVSWVR RKQDEWIKFD DDKVSIVTPE DILRLSGGGD WHIAYVLLYG PRRVEIMEEE SEQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
56,002 Da
Sequence Positions
1-493, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9JMA1
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Usp14 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Usp14 purchase

MBS1449959 is a recombinant protein targeting Usp14. Also known as Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 14 (Usp14). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Usp14. It may not necessarily be applicable to this product.

NCBI GI #
31560313
NCBI GeneID
59025
NCBI Accession #
NP_067497.2
UniProt Primary Accession #
Q9JMA1
UniProt Secondary Accession #
Q543U5; Q923F2; Q9D0L0
UniProt Related Accession #
Q9JMA1
GenBank Nucleotide #
NM_021522.4
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 14 isoform 1
NCBI Official Synonym Full Names
ubiquitin specific peptidase 14
NCBI Official Symbol
Usp14
NCBI Official Synonym Symbols
ax; C78769; nmf375; AW107924; 2610005K12Rik; 2610037B11Rik
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 14
UniProt Synonym Protein Names
Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14
UniProt Gene Name
Usp14
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 14

UniProt Comments for Usp14

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.
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Research Articles on Usp14

1. These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Usp14 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with Usp14 and Nervous System Diseases
 Neoplasms Antibodies  >6 publications with Usp14 and Neoplasms
 Disease Models, Animal Antibodies  >4 publications with Usp14 and Disease Models, Animal
 Carcinoma Antibodies  >3 publications with Usp14 and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with Usp14 and Adenocarcinoma
 Gonadal Disorders Antibodies  >2 publications with Usp14 and Gonadal Disorders
 Neoplasm Metastasis Antibodies  >2 publications with Usp14 and Neoplasm Metastasis
 Ovarian Neoplasms Antibodies  >2 publications with Usp14 and Ovarian Neoplasms
 Liver Diseases Antibodies  >2 publications with Usp14 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with Usp14 and Liver Neoplasms

Organs/Tissues associated with Usp14 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1 publications with Usp14 and Bone Marrow
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