Human APIP Recombinant Protein – Cat# MBS145010

APAF1 Interacting Protein (APIP) Human Recombinant Protein

Name: APIP Recombinant Protein; APAF1 Interacting Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145010
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145010

Description: APIP Human Recombinant produced E Coli is a single polypeptide chain containing 266 amino acids (1-242) and having a molecular mass of 29.7kDa.APIP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

APAF1 interacting protein (APIP), Recombinant Protein

Full Product Name

Recombinant Human APAF1 interacting protein

Product Gene Name

APIP recombinant protein

Product Synonym Names

APIP Human; APAF1 interacting protein Human Recombinant; APAF1 interacting protein; CGI-29; APIP2; Mmrp19; APAF1-interacting protein; MTRu-1-P dehydratase; probable methylthioribulose-1-phosphate dehydratase; CGI29; EC 4.2.1.109; dJ179L10.2; MMRP19

Sequence

MGSSHHH HHH SSGLVPRGSH MGSHMS GCDA REGDCCSRRC GAQDKEHPRY LIPELCKQFY HLGWVTGTGG GISLKHGDEI YIAPSGVQKE RIQPEDMFVC DINEKDISGP SPSKKLKKSQ CTPLFMNAYT MRGAGAVIHT HSKAAVMATL LFPGREFKIT HQEMIKGIKK CTSGGYYRYD DMLVVPIIEN TPEEKDLKDR MAHAMNEYPD SCAVLVRRHG VYVWGETWEK AKTMCECYDY LFDIAVSMKK VGLDPSQLPV GENGIV

Host

E Coli

Form/Format

The APIP solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 20% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 85% as determined by SDS-PAGE.

Molecular Weight

22,858 Da

OMIM

612491

3D Structure

ModBase 3D Structure for Q96GX9

Product Categories/Family for APIP recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of APIP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APIP purchase

MBS145010 is a recombinant protein targeting APIP. Also known as Recombinant Human APAF1 interacting protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for APIP. It may not necessarily be applicable to this product.

NCBI GI #

166235186

NCBI GeneID

51074

NCBI Accession #

NP_057041.2

UniProt Primary Accession #

Q96GX9

UniProt Secondary Accession #

Q6PJX6; Q8WVU2; Q96HK2; Q9Y318; A8K9D3

UniProt Related Accession #

Q96GX9

GenBank Nucleotide #

NM_015957.3

NCBI Official Full Name

methylthioribulose-1-phosphate dehydratase

NCBI Official Synonym Full Names

APAF1 interacting protein

NCBI Official Symbol

APIP

NCBI Official Synonym Symbols

APIP2; CGI29; hAPIP; CGI-29; MMRP19

UniProt Protein Name

Methylthioribulose-1-phosphate dehydratase

UniProt Synonym Protein Names

APAF1-interacting protein

UniProt Gene Name

APIP

UniProt Entry Name

MTNB_HUMAN

NCBI Protein Information

methylthioribulose-1-phosphate dehydratase; APAF1-interacting protein; APIP; MTRu-1-P dehydratase; probable methylthioribulose-1-phosphate dehydratase

NCBI Summary for APIP

APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]

UniProt Comments for APIP

MMRP19: Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c- dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - cysteine and methionine; Apoptosis; EC 4.2.1.109

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm

Molecular Function: identical protein binding; 5-methylthioribulose-1-phosphate 4-dehydratase activity; protein binding; zinc ion binding

Biological Process: methionine salvage; sulfur amino acid metabolic process; apoptosis; methionine biosynthetic process from S-adenosylmethionine; negative regulation of apoptosis; polyamine metabolic process

Research Articles on APIP

1. APIP/MtnB functions as a cell death inhibitor independently of its MtnB enzyme activity for apoptosis induced by either hypoxia or etoposide, but dependently for caspase-1-induced pyroptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with APIP recombinant protein

Reference Product	PubMed Publications
CASP9 recombinant protein	>7 publications with APIP and CASP9
APAF1 recombinant protein	>5 publications with APIP and APAF1

Pathways associated with APIP recombinant protein

Products by Pathway	Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Metabolism Of Polyamines Pathway antibodies	Metabolism Of Polyamines Pathway Diagram
Methionine Salvage Pathway antibodies	Methionine Salvage Pathway Diagram
Methionine Salvage Pathway antibodies	Methionine Salvage Pathway Diagram
Methionine Salvage Pathway antibodies	Methionine Salvage Pathway Diagram
S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation Pathway antibodies	S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation Pathway Diagram

Diseases associated with APIP recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>2 publications with APIP and Inflammation
Liver Diseases Antibodies	>1 publications with APIP and Liver Diseases
Fibrosis Antibodies	>1 publications with APIP and Fibrosis
Liver Neoplasms Antibodies	>1 publications with APIP and Liver Neoplasms

Organs/Tissues associated with APIP recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with APIP and Lung
Bone Antibodies	>1 publications with APIP and Bone
Heart Antibodies	>1 publications with APIP and Heart
Thymus Antibodies	>1 publications with APIP and Thymus
Prostate Antibodies	>1 publications with APIP and Prostate
Liver Antibodies	>1 publications with APIP and Liver
Muscle Antibodies	>1 publications with APIP and Muscle
Kidney Antibodies	>1 publications with APIP and Kidney
Bone Marrow Antibodies	>1 publications with APIP and Bone Marrow
Brain Antibodies	>1 publications with APIP and Brain