N-Myc Downstream Regulated 2 (NDRG2) Human Recombinant Protein

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

NDRG2: a pro-apoptotic protein that may be involved in dendritic cell and neuron differentiation. May have anti-tumor activity. Generally not expressed in tumor cell lines. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. The loss of NDRG2 expression has been shown to be a prognostic indicator in gastric carcinomas. Five isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease

Protein type: Apoptosis; Tumor suppressor

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; Golgi apparatus; centrosome; growth cone; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; cytosol

Molecular Function: protein binding

Biological Process: Wnt receptor signaling pathway; substantia nigra development; negative regulation of smooth muscle cell proliferation; negative regulation of cytokine production; cell differentiation