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Non-Metastatic Cells 3 (NME3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145074

Description: NME3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (22-169.a.a) and having a molecular mass of 19.1kDa. NME3 is fused to a 20 amino acid His-tag at N-terminus & purified by… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Non-Metastatic Cells 3 (NME3), Recombinant Protein
Full Product Name
Recombinant Human Non-Metastatic Cells 3
Product Gene Name
NME3 recombinant protein
Product Synonym Names
NME3 Human; Non-Metastatic Cells 3 Human Recombinant; Protein expressed in non-metastatic cells 3; DR-nm23; Nucleoside diphosphate kinase C; NDPKC; NDK 3; NDP kinase 3; EC 2.7.4.6; NM23H3; KIAA0516; NDPK-C; NM23-H3; c371H6.2; NDP kinase C; nucleoside diphosphate kinase 3; nm23-H3
Sequence
MGS SHHHHHH SSGLVPRGSH MERTFLAVKP DGVQRRLVGE IVRRFERKGF KLVALKLVQA SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV VRTSRALIGA TNPADAPPGT IRGDFCIEVG KNLIHGSDSV ESARREIALW FRADELLCWE DSAGHWLYE
Host
E Coli
Form/Format
The NME3 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 2mM DTT  and 50% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Molecular Weight
19,015 Da
OMIM
601817
3D Structure
ModBase 3D Structure for Q13232

Product Categories/Family for NME3 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Non-Metastatic Cells

Other Notes

Small volumes of NME3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NME3 purchase

MBS145074 is a recombinant protein targeting NME3. Also known as Recombinant Human Non-Metastatic Cells 3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NME3. It may not necessarily be applicable to this product.

NCBI GI #
37693993
NCBI GeneID
4832
NCBI Accession #
NP_002504.2
UniProt Primary Accession #
Q13232
UniProt Secondary Accession #
Q9BWH4
UniProt Related Accession #
Q13232
GenBank Nucleotide #
NM_002513.2
NCBI Official Full Name
nucleoside diphosphate kinase 3
NCBI Official Synonym Full Names
NME/NM23 nucleoside diphosphate kinase 3
NCBI Official Symbol
NME3
NCBI Official Synonym Symbols
NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2
UniProt Protein Name
Nucleoside diphosphate kinase 3
UniProt Synonym Protein Names
DR-nm23; Nucleoside diphosphate kinase C; NDPKC; nm23-H3
Protein Family
Nucleoside diphosphate kinase
UniProt Gene Name
NME3
UniProt Synonym Gene Names
NDK 3; NDP kinase 3; NDPKC
UniProt Entry Name
NDK3_HUMAN
NCBI Protein Information
nucleoside diphosphate kinase 3; NDK 3; NDP kinase 3; NDP kinase C; non-metastatic cells 3, protein expressed in; nucleoside diphosphate kinase C

UniProt Comments for NME3

NME3: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis. Belongs to the NDK family.

Protein type: Kinase, nucleoside diphosphate; Nucleotide Metabolism - pyrimidine; EC 2.7.4.6; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Apoptosis; Kinase, other; Other group; NDK family

Chromosomal Location of Human Ortholog: 16q13.3

Cellular Component: mitochondrion; cytosol

Molecular Function: metal ion binding; nucleoside diphosphate kinase activity; ATP binding

Biological Process: GTP biosynthetic process; regulation of apoptosis; CTP biosynthetic process; apoptosis; pyrimidine nucleotide metabolic process; UTP biosynthetic process; nucleoside triphosphate biosynthetic process; nucleoside diphosphate phosphorylation; purine nucleotide metabolic process
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Research Articles on NME3

1. Down-regulated DR-nm23 expression is associated with invasion and metastasis in colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NME3 recombinant protein

 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with NME3 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >3 publications with NME3 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >1 publications with NME3 and Breast Neoplasms
 Seizures Antibodies  >1 publications with NME3 and Seizures
 Disease Models, Animal Antibodies  >1 publications with NME3 and Disease Models, Animal

Organs/Tissues associated with NME3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with NME3 and Bone
 Intestine Antibodies  >2 publications with NME3 and Intestine
 Blood Antibodies  >2 publications with NME3 and Blood
 Embryonic Tissue Antibodies  >2 publications with NME3 and Embryonic Tissue
 Ovary Antibodies  >1 publications with NME3 and Ovary
 Lymph Antibodies  >1 publications with NME3 and Lymph
 Lung Antibodies  >1 publications with NME3 and Lung
 Muscle Antibodies  >1 publications with NME3 and Muscle
 Pancreas Antibodies  >1 publications with NME3 and Pancreas
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