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Interleukin-33 (rIL 33) Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145080

Description: IL 33 Rat Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 156 amino acids and having a molecular mass of 17.4kDa.The IL 33 is purified by proprietary chromatographic techniques.Introduction: Interleukin… More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-33 (rIL 33), Active Protein
Full Product Name
Recombinant Rat Interleukin-33
Product Gene Name
rIL 33 active protein
Product Synonym Names
IL 33 Rat; Interleukin-33 Rat Recombinant; Interleukin 33; DVS27; NF-HEV; NKHEV; C9orf26; Interleukin-1 family member 11; IL- 1F11; Nuclear factor from high endothelial venules; NFEHEV; DKFZp586H0523; RP11-575C20.2; IL-33
Sequence
SIQGTSLLTE SCALSTYNDQ SVSFVLENGC YVINVEDCGK NQEKDKVLLR YYESSFPAQS GDGVDGKKLM VNMSPIKDTD IWLNANDKDY SVELQKGDVS PPDQAFFVLH KKSSDFVSFE CKNLPGTYIG VKDNQLALVE ENDESCNNIM FKLSKM
Host
E Coli
Form/Format
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
3D Structure
ModBase 3D Structure for Q66H70
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized IL-33 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is <0.5ng/ml, corresponding to a specific activity of >2,000,000units/mg.

Product Categories/Family for rIL 33 active protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of rIL 33 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for rIL 33 purchase

MBS145080 is an active protein targeting rIL 33. Also known as Recombinant Rat Interleukin-33. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for rIL 33. It may not necessarily be applicable to this product.

NCBI GI #
62079057
NCBI GeneID
361749
NCBI Accession #
NP_001014188.1
UniProt Primary Accession #
Q66H70
UniProt Related Accession #
Q66H70
GenBank Nucleotide #
NM_001014166.1
NCBI Official Full Name
interleukin-33
NCBI Official Synonym Full Names
interleukin 33
NCBI Official Symbol
Il33
NCBI Official Synonym Symbols
RGD1311155
UniProt Protein Name
Interleukin-33
Protein Family
Interleukin
UniProt Gene Name
Il33
UniProt Synonym Gene Names
IL-33
UniProt Entry Name
IL33_RAT
NCBI Protein Information
interleukin-33; IL-33

UniProt Comments for rIL 33

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Cellular Component: extracellular space; transport vesicle; chromosome; nucleus

Molecular Function: cytokine activity

Biological Process: positive regulation of cytokine production; positive regulation of T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; defense response to virus; positive regulation of interleukin-5 production; positive regulation of inflammatory response; positive regulation of macrophage activation
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Research Articles on rIL 33

1. Induced interleukin-33 expression enhances the tumorigenic activity of rat glioma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with rIL 33 active protein

 Reference Product  PubMed Publications
 Il1rl1 active protein  >161 publications with rIL 33 and Il1rl1
 Tslp active protein  >19 publications with rIL 33 and Tslp
 Il18 active protein  >17 publications with rIL 33 and Il18
 Casp1 active protein  >17 publications with rIL 33 and Casp1
 Il18r1 active protein  >7 publications with rIL 33 and Il18r1
 Myd88 active protein  >6 publications with rIL 33 and Myd88
 Tlr4 active protein  >5 publications with rIL 33 and Tlr4
 Il9 active protein  >4 publications with rIL 33 and Il9
 Nlrp3 active protein  >4 publications with rIL 33 and Nlrp3
 Csf2 active protein  >1 publications with rIL 33 and Csf2

Pathways associated with rIL 33 active protein

 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram

Diseases associated with rIL 33 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >191 publications with rIL 33 and Inflammation
 Asthma Antibodies  >91 publications with rIL 33 and Asthma
 Hypersensitivity, Immediate Antibodies  >87 publications with rIL 33 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >86 publications with rIL 33 and Lung Diseases
 Necrosis Antibodies  >55 publications with rIL 33 and Necrosis
 Cardiovascular Diseases Antibodies  >51 publications with rIL 33 and Cardiovascular Diseases
 Heart Diseases Antibodies  >30 publications with rIL 33 and Heart Diseases
 Fibrosis Antibodies  >22 publications with rIL 33 and Fibrosis
 Disease Models, Animal Antibodies  >19 publications with rIL 33 and Disease Models, Animal
 Dermatitis, Atopic Antibodies  >18 publications with rIL 33 and Dermatitis, Atopic

Organs/Tissues associated with rIL 33 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >55 publications with rIL 33 and Lung
 Heart Antibodies  >43 publications with rIL 33 and Heart
 Liver Antibodies  >16 publications with rIL 33 and Liver
 Brain Antibodies  >12 publications with rIL 33 and Brain
 Eye Antibodies  >9 publications with rIL 33 and Eye
 Spleen Antibodies  >7 publications with rIL 33 and Spleen
 Kidney Antibodies  >6 publications with rIL 33 and Kidney
 Adipose Tissue Antibodies  >5 publications with rIL 33 and Adipose Tissue
 Colon Antibodies  >4 publications with rIL 33 and Colon
 Pancreas Antibodies  >3 publications with rIL 33 and Pancreas
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