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Interleukin-13 (rIL 13) Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145117

Description: Interleukin-13 Rat Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 109 amino acids and having a molecular mass of 11.9 kDa. The IL-13 is purified by proprietary chromatographic techniques.Introduction:… More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-13 (rIL 13), Active Protein
Full Product Name
Recombinant Rat Interleukin-13 109 a.a.
Product Gene Name
rIL 13 active protein
Product Synonym Names
IL 13 Rat 109 a.a.; Interleukin-13 109 a.a. Rat Recombinant; NC300; ALRH; BHR1; P600; IL-13; rIL 13 109 a.a.
Sequence
VRRSTSPPVA LRELIEELSN ITQDQKTSLC NSSIVWSVDI TAGGFCAALE SLTNISSCNA IHRTQRILNG LCNQKASDVA SSPPDTKIEV AQFISKLLNY SKQLFRYGH
Host
E Coli
Form/Format
The protein (1mg/ml) was lyophilized in PBS, pH7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Preparation and Storage
Lyophilized Interleukin-13 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL13 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Molecular Weight
14,093 Da
3D Structure
ModBase 3D Structure for P42203
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized Interleukin 13 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Protein Content
Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 0.69 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a calibrated solution of IL-13 as a Reference Standard.
Biological Activity
ED50 range = 40ng/ml, corresponding to a specific activity of > 25,000IU/mg as determined by the dose dependent proliferation of human TF-1 cells. Optimal concentration for individual application should be determined by a dose response assay.

Product Categories/Family for rIL 13 active protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of rIL 13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for rIL 13 purchase

MBS145117 is an active protein targeting rIL 13. Also known as Recombinant Rat Interleukin-13 109 a.a.. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for rIL 13. It may not necessarily be applicable to this product.

NCBI GI #
16758680
NCBI GeneID
116553
NCBI Accession #
NP_446280.1
UniProt Primary Accession #
P42203
UniProt Related Accession #
P42203
GenBank Nucleotide #
NM_053828.1
NCBI Official Full Name
interleukin-13
NCBI Official Synonym Full Names
interleukin 13
NCBI Official Symbol
Il13
UniProt Protein Name
Interleukin-13
UniProt Synonym Protein Names
T-cell activation protein P600
Protein Family
Interleukin-13 receptor
UniProt Gene Name
Il13
UniProt Synonym Gene Names
Il-13; IL-13
UniProt Entry Name
IL13_RAT
NCBI Protein Information
interleukin-13; IL-13; T-cell activation protein P600

NCBI Summary for rIL 13

cytokine; involved in inflammatory and immune responses [RGD, Feb 2006]

UniProt Comments for rIL 13

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function: interleukin-13 receptor binding; cytokine activity

Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; microglial cell activation; regulation of proton transport; positive regulation of mast cell degranulation; response to lipopolysaccharide; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; positive regulation of protein secretion; response to mechanical stimulus; positive regulation of B cell proliferation; immune response; positive regulation of ion transport; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; negative regulation of NAD(P)H oxidase activity; positive regulation of macrophage activation
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Research Articles on rIL 13

1. IL-13 significantly enhanced C/EBP-alpha/COX-2 expression and PGE2 production in LPS-treated microglial cells. Paradoxically, IL-13 abolished C/EBP-beta/PPAR-gamma/HO-1 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with rIL 13 active protein

 Reference Product  PubMed Publications
 Il4ra active protein  >879 publications with rIL 13 and Il4ra
 Stat6 active protein  >416 publications with rIL 13 and Stat6
 Il13ra1 active protein  >295 publications with rIL 13 and Il13ra1
 Il5 active protein  >116 publications with rIL 13 and Il5
 Il15 active protein  >60 publications with rIL 13 and Il15
 Il2 active protein  >60 publications with rIL 13 and Il2
 Nos2 active protein  >39 publications with rIL 13 and Nos2
 Il9 active protein  >27 publications with rIL 13 and Il9
 Csf2 active protein  >13 publications with rIL 13 and Csf2

Pathways associated with rIL 13 active protein

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with rIL 13 active protein

 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >1408 publications with rIL 13 and Hypersensitivity
 Inflammation Antibodies  >1354 publications with rIL 13 and Inflammation
 Asthma Antibodies  >1299 publications with rIL 13 and Asthma
 Hypersensitivity, Immediate Antibodies  >1224 publications with rIL 13 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >1209 publications with rIL 13 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >1019 publications with rIL 13 and Respiratory Hypersensitivity
 Necrosis Antibodies  >642 publications with rIL 13 and Necrosis
 Fibrosis Antibodies  >337 publications with rIL 13 and Fibrosis
 Bronchial Hyperreactivity Antibodies  >233 publications with rIL 13 and Bronchial Hyperreactivity
 Dermatitis, Atopic Antibodies  >187 publications with rIL 13 and Dermatitis, Atopic
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