Human THG1L Recombinant Protein – Cat# MBS145177

Trna-Histidine Guanylyltransferase 1-Like (THG1L) Human Recombinant Protein

Name: THG1L Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145177
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145177

Description: THG1L Human Recombinant produced in E Coli is a single polypeptide chain containing 292 amino acids (30-298) and having a molecular mass of 34.0 kDa.THG1L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

tRNA-Histidine Guanylyltransferase 1-Like (THG1L), Recombinant Protein

Full Product Name

Recombinant Human tRNA-Histidine Guanylyltransferase 1-Like

Product Gene Name

THG1L recombinant protein

Product Synonym Names

THG1L Human; tRNA-Histidine Guanylyltransferase 1-Like Human Recombinant; tRNA-histidine guanylyltransferase 1-like (S. cerevisiae); Interphase cytoplasmic foci protein 45; probable tRNA(His) guanylyltransferase; induced by high glucose-1; FLJ11601; FLJ20546; ICF45; IHG-1; EC 2.7.7.79; EC 2.7.7.6

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMAK SKFE YVRDFEADDT CLAHCWVVVR LDGRNFHRFA EKHNFAKPND SRALQLMTKC AQTVMEELED IVIAYGQSDE YSFVFKRKTN WFKRRASKFM THVASQFASS YVFYWRDYFE DQPLLYPPGF DGRVVVYPSN QTLKDYLSWR QADCHINNLY NTVFWALIQQ SGLTPVQAQG RLQGTLAADK NEILFSEFNI NYNNELPMYR KGTVLIWQKV DEVMTKEIKL PTEMEGKKMA VTRTRTKPVP LHCDIIGDAF WKEHPEILDE DS

Host

E Coli

Form/Format

The THG1L solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 20% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Molecular Weight

34,831 Da

3D Structure

ModBase 3D Structure for Q9NWX6

Product Categories/Family for THG1L recombinant protein

Enzymes; Transferase

Other Notes

Small volumes of THG1L recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THG1L purchase

MBS145177 is a recombinant protein targeting THG1L. Also known as Recombinant Human tRNA-Histidine Guanylyltransferase 1-Like. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for THG1L. It may not necessarily be applicable to this product.

NCBI GI #

89242148

NCBI GeneID

54974

NCBI Accession #

NP_060342.2

UniProt Primary Accession #

Q9NWX6

UniProt Secondary Accession #

Q53G12; Q7L5R3; Q9H0S2; D3DQJ5

UniProt Related Accession #

Q9NWX6

GenBank Nucleotide #

NM_017872.3

NCBI Official Full Name

probable tRNA(His) guanylyltransferase

NCBI Official Synonym Full Names

tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)

NCBI Official Symbol

THG1L

NCBI Official Synonym Symbols

ICF45; IHG-1

UniProt Protein Name

Probable tRNA(His) guanylyltransferase

UniProt Synonym Protein Names

Interphase cytoplasmic foci protein 45; tRNA-histidine guanylyltransferase

UniProt Gene Name

THG1L

UniProt Synonym Gene Names

ICF45

UniProt Entry Name

THG1_HUMAN

NCBI Protein Information

probable tRNA(His) guanylyltransferase; probable tRNA(His) guanylyltransferase; induced by high glucose-1; interphase cytoplasmic foci protein 45

UniProt Comments for THG1L

ICF45: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Belongs to the tRNA(His) guanylyltransferase family.

Protein type: Transferase; Mitochondrial; EC 2.7.7.79; Cell cycle regulation

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: mitochondrion; cytoplasm

Molecular Function: identical protein binding; tRNA guanylyltransferase activity; GTP binding; magnesium ion binding; ATP binding; tRNA binding

Biological Process: tRNA processing; tRNA modification; protein homotetramerization

Research Articles on THG1L

1. IHG-1 is a novel regulator of both mitochondrial dynamics and bioenergetic function and contributes to cell survival following oxidant stress. Increased IHG-1 expression may contribute to pathogenesis of diabetic kidney disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.