Human SNIP1 Recombinant Protein – Cat# MBS145190

Smad Nuclear Interacting Protein 1 (SNIP1) Human Recombinant Protein

Name: SNIP1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145190
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145190

Description: SNIP1 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 160 amino acids (258-396 a.a.) and having a molecular mass of 18.8kDa. The SNIP1 is purified… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Smad Nuclear Interacting Protein 1 (SNIP1), Recombinant Protein

Full Product Name

Recombinant Human Smad Nuclear Interacting Protein 1

Product Gene Name

SNIP1 recombinant protein

Product Synonym Names

SNIP1 Human; Smad Nuclear Interacting Protein 1 Human Recombinant; Smad nuclear-interacting protein 1; FHA domain-containing protein SNIP1; SNIP1; FLJ12553; dJ423B22.2; RP3-423B22.3

Sequence

MGSSHHH HHH SSGLVPRGSH MRWRLY PFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVF QYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDT SEIDRKDDED EEEEEEVSDS .

Host

E Coli

Form/Format

The SNIP1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 20% glycerol and 100mM NaCl.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

SNIP1 should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Molecular Weight

45,778 Da

OMIM

608241

3D Structure

ModBase 3D Structure for Q8TAD8

Product Categories/Family for SNIP1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of SNIP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNIP1 purchase

MBS145190 is a recombinant protein targeting SNIP1. Also known as Recombinant Human Smad Nuclear Interacting Protein 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SNIP1. It may not necessarily be applicable to this product.

NCBI GI #

21314720

NCBI GeneID

79753

NCBI Accession #

NP_078976.2

UniProt Primary Accession #

Q8TAD8

UniProt Secondary Accession #

Q96SP9; Q9H9T7

UniProt Related Accession #

Q8TAD8

GenBank Nucleotide #

NM_024700.3

NCBI Official Full Name

smad nuclear-interacting protein 1

NCBI Official Synonym Full Names

Smad nuclear interacting protein 1

NCBI Official Symbol

SNIP1

NCBI Official Synonym Symbols

PMRED

UniProt Protein Name

Smad nuclear-interacting protein 1

UniProt Synonym Protein Names

FHA domain-containing protein SNIP1

Protein Family

Smad nuclear interacting protein

UniProt Gene Name

SNIP1

UniProt Entry Name

SNIP1_HUMAN

NCBI Protein Information

smad nuclear-interacting protein 1; FHA domain-containing protein SNIP1

NCBI Summary for SNIP1

This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]

UniProt Comments for SNIP1

SNIP1: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. Defects in SNIP1 are the cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; miRNA-mediated gene silencing, production of miRNAs; regulation of transcription, DNA-dependent

Disease: Psychomotor Retardation, Epilepsy, And Craniofacial Dysmorphism

Research Articles on SNIP1

1. Involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SNIP1 recombinant protein

Reference Product	PubMed Publications
SMAD2 recombinant protein	>2 publications with SNIP1 and SMAD2
SMAD4 recombinant protein	>2 publications with SNIP1 and SMAD4

Pathways associated with SNIP1 recombinant protein

Products by Pathway	Pathway Diagram
Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies	Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
TGF-beta Receptor Signaling Pathway antibodies	TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with SNIP1 recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>1 publications with SNIP1 and Heart Diseases

Organs/Tissues associated with SNIP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>2 publications with SNIP1 and Bone
Heart Antibodies	>2 publications with SNIP1 and Heart
Lung Antibodies	>2 publications with SNIP1 and Lung
Brain Antibodies	>2 publications with SNIP1 and Brain
Connective Tissue Antibodies	>1 publications with SNIP1 and Connective Tissue
Mammary Gland Antibodies	>1 publications with SNIP1 and Mammary Gland
Kidney Antibodies	>1 publications with SNIP1 and Kidney
Embryonic Tissue Antibodies	>1 publications with SNIP1 and Embryonic Tissue
Muscle Antibodies	>1 publications with SNIP1 and Muscle
Skin Antibodies	>1 publications with SNIP1 and Skin