Mouse mOSM Active Protein – Cat# MBS145205

Oncostatin-M (mOSM) Mouse Active Protein

Name: mOSM Active Protein; Oncostatin-M; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS145205
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145205

Description: OSM Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 181 amino acids and having a molecular mass of 20.4kDa.The OSM is purified by proprietary chromatographic techniques.Introduction: Oncostatin M is… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Oncostatin-M (mOSM), Active Protein

Full Product Name

Recombinant Mouse Oncostatin-M

Product Gene Name

mOSM active protein

Product Synonym Names

OSM Mouse; Oncostatin-M Mouse Recombinant; Oncostatin-M; OSM; OncoM

Sequence

NRGCSNSSSQ LLSQLQNQAN LTGNTESLLE PYIRLQNLNT PDLRAACTQH SVAFPSEDTL RQLSKPHFLS TVYTTLDRVL YQLDALRQKF LKTPAFPKLD SARHNILGIR NNVFCMARLL NHSLEIPEPT QTDSGASRST TTPDVFNTKI GSCGFLWGYH RFMGSVGRVF REWDDGSTRS R

Host

E Coli

Form/Format

OSM protein was lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized Oncostatin M although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Oncostatin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

30,114 Da

3D Structure

ModBase 3D Structure for P53347

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized Oncostatin M in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

The ED50 as determined by the dose-dependent stimulation of the proliferation of NIH-3T3 mouse embryonic fibroblast cells is < 1 ng/ml, corresponding to a specific activity of > 1.0x106 units/mg.

Product Categories/Family for mOSM active protein

Cytokines and Growth Factors; Growth Factors; Oncostatin-M

Other Notes

Small volumes of mOSM active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mOSM purchase

MBS145205 is an active protein targeting mOSM. Also known as Recombinant Mouse Oncostatin-M. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mOSM. It may not necessarily be applicable to this product.

NCBI GI #

61656173

NCBI GeneID

18413

NCBI Accession #

NP_001013383.1

UniProt Primary Accession #

P53347

UniProt Secondary Accession #

Q3U1Y5; Q5SPX6

UniProt Related Accession #

P53347

GenBank Nucleotide #

NM_001013365.2

NCBI Official Full Name

oncostatin-M

NCBI Official Synonym Full Names

oncostatin M

NCBI Official Symbol

Osm

NCBI Official Synonym Symbols

OncoM

UniProt Protein Name

Oncostatin-M

Protein Family

Oncostatin-M-specific receptor

UniProt Gene Name

Osm

UniProt Synonym Gene Names

OSM

UniProt Entry Name

ONCM_MOUSE

NCBI Protein Information

oncostatin-M

UniProt Comments for mOSM

OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity

Biological Process: negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat5 protein; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; negative regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; response to heat; regulation of growth; negative regulation of meiosis; positive regulation of cell proliferation; tyrosine phosphorylation of Stat1 protein; immune response; positive regulation of transcription from RNA polymerase II promoter

Research Articles on mOSM

1. OSM promotes tumour growth, and does so through altering the local lung environment with accumulation of M2 macrophages.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mOSM active protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with mOSM active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>212 publications with mOSM and Inflammation
Necrosis Antibodies	>152 publications with mOSM and Necrosis
Liver Diseases Antibodies	>74 publications with mOSM and Liver Diseases
Disease Models, Animal Antibodies	>70 publications with mOSM and Disease Models, Animal
Kidney Diseases Antibodies	>54 publications with mOSM and Kidney Diseases
Fibrosis Antibodies	>48 publications with mOSM and Fibrosis
Breast Neoplasms Antibodies	>44 publications with mOSM and Breast Neoplasms
Lung Diseases Antibodies	>38 publications with mOSM and Lung Diseases
Neoplasms, Experimental Antibodies	>29 publications with mOSM and Neoplasms, Experimental
Lung Neoplasms Antibodies	>25 publications with mOSM and Lung Neoplasms

Organs/Tissues associated with mOSM active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>461 publications with mOSM and Blood
Bone Antibodies	>183 publications with mOSM and Bone
Lung Antibodies	>99 publications with mOSM and Lung
Heart Antibodies	>83 publications with mOSM and Heart
Skin Antibodies	>57 publications with mOSM and Skin
Spleen Antibodies	>21 publications with mOSM and Spleen
Lymph Node Antibodies	>20 publications with mOSM and Lymph Node
Thymus Antibodies	>17 publications with mOSM and Thymus
Inner Ear Antibodies	>6 publications with mOSM and Inner Ear
Uncharacterized Tissue Antibodies	>2 publications with mOSM and Uncharacterized Tissue