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TNF Ligand Receptor Superfamily (TNFRSF12A) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145232

Description: TNFRSF12A Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 53 amino acids and having a molecular mass of 5.6 KDa.The TNFRSF12A is purified by proprietary chromatographic techniques. More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TNF Ligand Receptor Superfamily (TNFRSF12A), Active Protein
Full Product Name
Recombinant Human TNF Ligand Receptor Superfamily Member 12A
Product Gene Name
TNFRSF12A active protein
Product Synonym Names
TNFRSF12A Human; TNF Ligand Receptor Superfamily Member 12A Human Recombinant; Tumor necrosis factor receptor superfamily member 12A; FN14; CD266 antigen; TweakR; tweak-receptor; Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; type I transmembrane protein Fn14
Sequence
EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
Host
E Coli
Form/Format
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Preparation and Storage
Lyophilized TNFRSF12A although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TNFRSF12A should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Molecular Weight
10,191 Da
OMIM
605914
3D Structure
ModBase 3D Structure for Q9NP84
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized TNFRSF12A in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The TNFRSF12A biological activity is determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-5.0ug/ml in the presence of 1ug/ml rhTWEAK.

Product Categories/Family for TNFRSF12A active protein

Cytokines and Growth Factors; Cytokines; Tumor Necrosis Factor

Other Notes

Small volumes of TNFRSF12A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF12A purchase

MBS145232 is an active protein targeting TNFRSF12A. Also known as Recombinant Human TNF Ligand Receptor Superfamily Member 12A. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF12A. It may not necessarily be applicable to this product.

NCBI GI #
7706186
NCBI GeneID
51330
NCBI Accession #
NP_057723.1
UniProt Primary Accession #
Q9NP84
UniProt Secondary Accession #
Q9HCS0; D3DUA6
UniProt Related Accession #
Q9NP84
GenBank Nucleotide #
NM_016639.2
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 12A
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 12A
NCBI Official Symbol
TNFRSF12A
NCBI Official Synonym Symbols
FN14; CD266; TWEAKR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 12A
UniProt Synonym Protein Names
Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF12A
UniProt Synonym Gene Names
FN14; FGF-inducible 14; TweakR
UniProt Entry Name
TNR12_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; tweak-receptor; type I transmembrane protein Fn14

UniProt Comments for TNFRSF12A

TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; positive regulation of axon extension; angiogenesis; regulation of angiogenesis
Show more

Research Articles on TNFRSF12A

1. Results position TWEAK-Fn14 signaling through Mcl-1 as a significant mechanism for NSCLC tumor cell survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFRSF12A active protein

 Reference Product  PubMed Publications
 TNFSF12 active protein  >5 publications with TNFRSF12A and TNFSF12
 TNFRSF25 active protein  >1 publications with TNFRSF12A and TNFRSF25

Pathways associated with TNFRSF12A active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TWEAK Signaling Pathway antibodies  TWEAK Signaling Pathway Diagram

Diseases associated with TNFRSF12A active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >14 publications with TNFRSF12A and Necrosis
 Inflammation Antibodies  >9 publications with TNFRSF12A and Inflammation
 Neoplasms, Experimental Antibodies  >4 publications with TNFRSF12A and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >3 publications with TNFRSF12A and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with TNFRSF12A and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >3 publications with TNFRSF12A and Adenocarcinoma
 Lung Diseases Antibodies  >3 publications with TNFRSF12A and Lung Diseases
 Heart Diseases Antibodies  >2 publications with TNFRSF12A and Heart Diseases
 Disease Models, Animal Antibodies  >2 publications with TNFRSF12A and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with TNFRSF12A and Breast Neoplasms

Organs/Tissues associated with TNFRSF12A active protein

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >7 publications with TNFRSF12A and Vascular
 Lung Antibodies  >7 publications with TNFRSF12A and Lung
 Muscle Antibodies  >5 publications with TNFRSF12A and Muscle
 Blood Antibodies  >4 publications with TNFRSF12A and Blood
 Eye Antibodies  >3 publications with TNFRSF12A and Eye
 Kidney Antibodies  >2 publications with TNFRSF12A and Kidney
 Heart Antibodies  >2 publications with TNFRSF12A and Heart
 Bone Antibodies  >2 publications with TNFRSF12A and Bone
 Brain Antibodies  >1 publications with TNFRSF12A and Brain
 Intestine Antibodies  >1 publications with TNFRSF12A and Intestine
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