Human HBXIP Recombinant Protein – Cat# MBS145269

Hepatitis B Virus X Interacting (HBXIP) Human Recombinant Protein

Name: HBXIP Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145269
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145269

Description: HBXIP Human Recombinant produced in E Coli is a single polypeptide chain containing 197 amino acids (aa 1-173) and having a molecular mass of 20.7kDa.HBXIP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hepatitis B Virus x Interacting (HBXIP), Recombinant Protein

Full Product Name

Recombinant Human Hepatitis B Virus x Interacting Protein

Product Gene Name

HBXIP recombinant protein

Product Synonym Names

HBXIP Human; Hepatitis B Virus x Interacting Protein Human Recombinant; Ragulator complex protein LAMTOR5; Hepatitis B virus X-interacting protein; HBV X-interacting protein; HBX-interacting protein; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5; LAMTOR5; HBXIP; XIP

Sequence

MGSSHHH HHH SSGLVPRGSH MGSHME PGAG HLDGHRAGSP SLRQALCDGS AVMFSSKERG RCTVINFVPL EAPLRSTPRS RQVTEACGGE GRAVPLGSEP EWSVGGMEAT LEQHLEDTMK NPSIVGVLCT DSQGLNLGCR GTLSDEHAGV ISVLAQQAAK LTSDPTDIPV VCLESDNGNI MIQKHDGITV AVHKMAS

Host

E Coli

Form/Format

The HBXIP solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM EDTA.
Sterile filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

9,614 Da

OMIM

608521

3D Structure

ModBase 3D Structure for O43504

Product Categories/Family for HBXIP recombinant protein

Viral Antigens; HEPATITIS B VIRUS; Viral Antigens; Hepatitis B

Other Notes

Small volumes of HBXIP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HBXIP purchase

MBS145269 is a recombinant protein targeting HBXIP. Also known as Recombinant Human Hepatitis B Virus x Interacting Protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HBXIP. It may not necessarily be applicable to this product.

NCBI GI #

38788353

NCBI GeneID

10542

NCBI Accession #

NP_006393.2

UniProt Primary Accession #

O43504

UniProt Secondary Accession #

Q6IBD8

UniProt Related Accession #

O43504

GenBank Nucleotide #

NM_006402.2

NCBI Official Full Name

ragulator complex protein LAMTOR5

NCBI Official Synonym Full Names

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

NCBI Official Symbol

LAMTOR5

NCBI Official Synonym Symbols

XIP; HBXIP

UniProt Protein Name

Ragulator complex protein LAMTOR5

UniProt Synonym Protein Names

Hepatitis B virus X-interacting protein; HBV X-interacting protein; HBX-interacting protein; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

Protein Family

Ragulator complex protein

UniProt Gene Name

LAMTOR5

UniProt Synonym Gene Names

HBXIP; XIP; HBV X-interacting protein; HBX-interacting protein

UniProt Entry Name

LTOR5_HUMAN

NCBI Protein Information

ragulator complex protein LAMTOR5; HBV X-interacting protein; HBx-interacting protein; hepatitis B virus x interacting protein; hepatitis B virus x-interacting protein (9.6kD); late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

NCBI Summary for HBXIP

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

UniProt Comments for HBXIP

HBXIP: When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. Belongs to the HBXIP family.

Protein type: DNA replication; Apoptosis

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: lysosome; cytosol

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold

Biological Process: response to virus; viral genome replication; negative regulation of caspase activity; regulation of cell size; positive regulation of TOR signaling pathway; negative regulation of apoptosis; positive regulation of GTPase activity

Research Articles on HBXIP

1. Dta show that HBXIP was able to stimulate the activity of Skp2 promoter via transcription factor Sp1 thus promoting the migration of ovarian cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HBXIP recombinant protein

Products by Pathway	Pathway Diagram
Hepatitis B Pathway antibodies	Hepatitis B Pathway Diagram