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GDP-Mannose 4,6-Dehydratase (GMDS) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145309

Description: GMDS Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 392 amino acids (1-372) and having a molecular mass of 44.1 kDa.GMDS is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GDP-Mannose 4,6-Dehydratase (GMDS), Recombinant Protein
Full Product Name
Recombinant Human GDP-Mannose 4,6-Dehydratase
Product Gene Name
Product Synonym Names
GMDS Human; GDP-Mannose 4,6-Dehydratase Human Recombinant; GDP-mannose 4; 6-dehydratase; GMD; SDR3E1; short chain dehydrogenase/reductase family 3E member 1; GDP-D-mannose dehydratase; EC 4.2.1.47
Sequence
MGSSHHH HHH SSGLVPRGSH MAHAPARCPS ARGSGDGEMG KPRNVALITG ITGQDGSYLA EFLLEKGYEV HGIVRRSSSF NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV KPTEIYNLGA QSHVKISFDL AEYTADVDGV GTLRLLDAVK TCGLINSVKF YQASTSELYG KVQEIPQKET TPFYPRSPYG AAKLYAYWIV VNFREAYNLF AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL GNLDAKRDWG HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFL HIGKTIVWEG KNENEVGRCK ETGKVHVTVD LKYYRPTEVD FLQGDCTKAK QKLNWKPRVA FDELVREMVH ADVELMRTNP NA.
Host
E Coli
Form/Format
The GMDS solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl, 0.1mM PMSF and 30% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Molecular Weight
39,054 Da
OMIM
602884
3D Structure
ModBase 3D Structure for O60547

Product Categories/Family for GMDS recombinant protein

Other Notes

Small volumes of GMDS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GMDS purchase

MBS145309 is a recombinant protein targeting GMDS. Also known as Recombinant Human GDP-Mannose 4,6-Dehydratase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GMDS. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
GDP-mannose 4,6 dehydratase isoform 2
NCBI Official Synonym Full Names
GDP-mannose 4,6-dehydratase
NCBI Official Symbol
GMDS
NCBI Official Synonym Symbols
GMD; SDR3E1
UniProt Protein Name
GDP-mannose 4,6 dehydratase
UniProt Synonym Protein Names
GDP-D-mannose dehydratase; GMD
UniProt Gene Name
GMDS
UniProt Synonym Gene Names
GMD
UniProt Entry Name
GMDS_HUMAN
NCBI Protein Information
GDP-mannose 4,6 dehydratase; GDP-D-mannose dehydratase; short chain dehydrogenase/reductase family 3E, member 1

NCBI Summary for GMDS

GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
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UniProt Comments for GMDS

GMD: an enzyme that converts GDP-D-mannose to GDP-4-keto-6-D- deoxymannose. Perticipates in the extravasation of activated lymphocytes.

Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Lyase; Carbohydrate Metabolism - fructose and mannose; EC 4.2.1.47

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: cytoplasm

Molecular Function: GDP-mannose 4,6-dehydratase activity

Biological Process: Notch signaling pathway; GDP-mannose metabolic process; 'de novo' GDP-L-fucose biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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