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Signal Transduction Protein CBL-C (CBLC) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1453296

MBS1453296 is a recombinant protein targeting CBLC. Also known as Recombinant Human Signal transduction protein CBL-C (CBLC). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1255 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Signal transduction protein CBL-C (CBLC), Recombinant Protein
Full Product Name
Recombinant Human Signal transduction protein CBL-C (CBLC)
Product Gene Name
CBLC recombinant protein
Product Synonym Gene Name
CBLC
Sequence
MALAVAPWGR QWEEARALGR AVRMLQRLEE QCVDPRLSVS PPSLRDLLPR TAQLLREVAH SRRAAGGGGP GGPGGSGDFL LIYLANLEAK SRQVAALLPP RGRRSANDEL FRAGSRLRRQ LAKLAIIFSH MHAELHALFP GGKYCGHMYQ LTKAPAHTFW RESCGARCVL PWAEFESLLG TCHPVEPGCT ALALRTTIDL TCSGHVSIFE FDVFTRLFQP WPTLLKNWQL LAVNHPGYMA FLTYDEVQER LQACRDKPGS YIFRPSCTRL GQWAIGYVSS DGSILQTIPA NKPLSQVLLE GQKDGFYLYP DGKTHNPDLT ELGQAEPQQR IHVSEEQLQL YWAMDSTFEL CKICAESNKD VKIEPCGHLL CSCCLAAWQH SDSQTCPFCR CEIKGWEAVS IYQFHGQATA EDSGNSSDQE GRELELGQVP LSAPPLPPRP DLPPRKPRNA QPKVRLLKGN SPPAALGPQD PAPA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
47,418 Da
Sequence Positions
1-474, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
608453
3D Structure
ModBase 3D Structure for Q9ULV8
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CBLC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CBLC. It may not necessarily be applicable to this product.

NCBI GI #
195927030
NCBI GeneID
23624
NCBI Accession #
NP_001124324.1
UniProt Primary Accession #
Q9ULV8
UniProt Secondary Accession #
Q8N1E5; Q9Y5Z2; Q9Y5Z3
UniProt Related Accession #
Q9ULV8
GenBank Nucleotide #
NM_001130852.1
NCBI Official Full Name
E3 ubiquitin-protein ligase CBL-C isoform 2
NCBI Official Synonym Full Names
Cbl proto-oncogene C
NCBI Official Symbol
CBLC
NCBI Official Synonym Symbols
CBL-3; RNF57; CBL-SL
UniProt Protein Name
E3 ubiquitin-protein ligase CBL-C
UniProt Synonym Protein Names
RING finger protein 57; RING-type E3 ubiquitin transferase CBL-CCurated; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
CBLC
UniProt Synonym Gene Names
CBL3; RNF57
NCBI Protein Information
E3 ubiquitin-protein ligase CBL-C

NCBI Summary for CBLC

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
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UniProt Comments for CBLC

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
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Research Articles on CBLC

1. Methylmalonic aciduria with homocystinuria cblC is a multisystemic metabolic disease affecting cobalamin metabolism. The presence of retinal alterations in cblC is a common feature and it is reported to develop more frequently and into a more severe form in the early-onset phenotype, suggesting to some extent a correlation with the biochemical phenotype
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CBLC recombinant protein

 Reference Product  PubMed Publications
 SRC recombinant protein  >4 publications with CBLC and SRC
 EGFR recombinant protein  >3 publications with CBLC and EGFR
 ITCH recombinant protein  >1 publications with CBLC and ITCH

Pathways associated with CBLC recombinant protein

 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram

Diseases associated with CBLC recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with CBLC and Neoplasms
 Congenital Abnormalities Antibodies  >5 publications with CBLC and Congenital Abnormalities
 Atrophy Antibodies  >4 publications with CBLC and Atrophy
 Edema Antibodies  >2 publications with CBLC and Edema
 Skin Diseases Antibodies  >2 publications with CBLC and Skin Diseases
 Heart Defects, Congenital Antibodies  >2 publications with CBLC and Heart Defects, Congenital
 Growth Disorders Antibodies  >2 publications with CBLC and Growth Disorders
 Hypertension Antibodies  >2 publications with CBLC and Hypertension
 Heart Septal Defects, Ventricular Antibodies  >2 publications with CBLC and Heart Septal Defects, Ventricular
 Cell Transformation, Neoplastic Antibodies  >2 publications with CBLC and Cell Transformation, Neoplastic

Organs/Tissues associated with CBLC recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >8 publications with CBLC and Skin
 Brain Antibodies  >7 publications with CBLC and Brain
 Mammary Gland Antibodies  >1 publications with CBLC and Mammary Gland
 Lung Antibodies  >1 publications with CBLC and Lung
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