Human GPX2 Recombinant Protein – Cat# MBS145341

Glutathione Peroxidase 2 (GPX2) Human Recombinant Protein

Name: GPX2 Recombinant Protein; Glutathione Peroxidase 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145341
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145341

Description: GPX2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-190) and having a molecular mass of 24.1kDa.GPX2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glutathione Peroxidase 2 (GPX2), Recombinant Protein

Full Product Name

Recombinant Human Glutathione Peroxidase 2

Product Gene Name

GPX2 recombinant protein

Product Synonym Names

GPX2 Human; Glutathione Peroxidase 2 Human Recombinant; Glutathione peroxidase 2; GPx-2; GSHPx-2; Gastrointestinal glutathione peroxidase; Glutathione peroxidase-gastrointestinal; GPx-GI; GSHPx-GI; Glutathione peroxidase-related protein 2; GPRP-2; GPX2; GPRP; GI-GPx

Sequence

MGSSHHH HHH SSGLVPRGSH MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLC GTTTRDFTQL NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI .

Host

E Coli

Form/Format

The GPX2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH7.5), 40% glycerol, 0.15M NaCl and 1mM DTT.
Sterile filtered colorless solution.

Purity/Purification

Greater than 95% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

21,954 Da

OMIM

138319

3D Structure

ModBase 3D Structure for P18283

Product Categories/Family for GPX2 recombinant protein

Enzymes; Oxidase

Other Notes

Small volumes of GPX2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPX2 purchase

MBS145341 is a recombinant protein targeting GPX2. Also known as Recombinant Human Glutathione Peroxidase 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GPX2. It may not necessarily be applicable to this product.

NCBI GI #

32967607

NCBI GeneID

2877

NCBI Accession #

NP_002074.2

UniProt Primary Accession #

P18283

UniProt Secondary Accession #

Q6PJ52; Q8WWI7; Q9NRP9

UniProt Related Accession #

P18283

GenBank Nucleotide #

NM_002083.3

NCBI Official Full Name

glutathione peroxidase 2

NCBI Official Synonym Full Names

glutathione peroxidase 2

NCBI Official Symbol

GPX2

NCBI Official Synonym Symbols

GPRP; GPx-2; GI-GPx; GPRP-2; GPx-GI; GSHPx-2; GSHPX-GI

UniProt Protein Name

Glutathione peroxidase 2

UniProt Synonym Protein Names

Gastrointestinal glutathione peroxidase; Glutathione peroxidase-gastrointestinal; GPx-GI; GSHPx-GI; Glutathione peroxidase-related protein 2; GPRP-2

Protein Family

Glutathione peroxidase

UniProt Gene Name

GPX2

UniProt Synonym Gene Names

GPx-2; GSHPx-2; GPx-GI; GSHPx-GI; GPRP-2

UniProt Entry Name

GPX2_HUMAN

NCBI Protein Information

glutathione peroxidase 2; gastrointestinal glutathione peroxidase; glutathione peroxidase 2 (gastrointestinal); glutathione peroxidase-related protein 2

NCBI Summary for GPX2

This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

UniProt Comments for GPX2

GPX2: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. Belongs to the glutathione peroxidase family.

Protein type: EC 1.11.1.9; Oxidoreductase; Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: cytoplasm; cytosol

Molecular Function: electron carrier activity; glutathione peroxidase activity

Biological Process: response to reactive oxygen species; response to symbiotic bacterium; negative regulation of inflammatory response to antigenic stimulus; thermoregulation; interaction with symbiont

Research Articles on GPX2

1. Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those with no GPX2 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GPX2 recombinant protein

Reference Product	PubMed Publications
GSTP1 recombinant protein	>6 publications with GPX2 and GSTP1
GSR recombinant protein	>5 publications with GPX2 and GSR
GSTM3 recombinant protein	>4 publications with GPX2 and GSTM3
GSTM2 recombinant protein	>2 publications with GPX2 and GSTM2
GSTA1 recombinant protein	>2 publications with GPX2 and GSTA1
GSTA4 recombinant protein	>2 publications with GPX2 and GSTA4
GSTA2 recombinant protein	>2 publications with GPX2 and GSTA2
GSTO1 recombinant protein	>1 publications with GPX2 and GSTO1
GSS recombinant protein	>1 publications with GPX2 and GSS

Pathways associated with GPX2 recombinant protein

Products by Pathway	Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Folate Metabolism Pathway antibodies	Folate Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram

Diseases associated with GPX2 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>35 publications with GPX2 and Inflammation
Liver Diseases Antibodies	>28 publications with GPX2 and Liver Diseases
Liver Neoplasms Antibodies	>22 publications with GPX2 and Liver Neoplasms
Neoplasms, Experimental Antibodies	>17 publications with GPX2 and Neoplasms, Experimental
Liver Neoplasms, Experimental Antibodies	>13 publications with GPX2 and Liver Neoplasms, Experimental
Lung Diseases Antibodies	>13 publications with GPX2 and Lung Diseases
Cell Transformation, Neoplastic Antibodies	>9 publications with GPX2 and Cell Transformation, Neoplastic
Necrosis Antibodies	>8 publications with GPX2 and Necrosis
Breast Neoplasms Antibodies	>6 publications with GPX2 and Breast Neoplasms
Cardiovascular Diseases Antibodies	>5 publications with GPX2 and Cardiovascular Diseases

Organs/Tissues associated with GPX2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>51 publications with GPX2 and Liver
Intestine Antibodies	>44 publications with GPX2 and Intestine
Lung Antibodies	>23 publications with GPX2 and Lung
Prostate Antibodies	>9 publications with GPX2 and Prostate
Kidney Antibodies	>7 publications with GPX2 and Kidney
Skin Antibodies	>6 publications with GPX2 and Skin
Ovary Antibodies	>4 publications with GPX2 and Ovary
Brain Antibodies	>3 publications with GPX2 and Brain
Esophagus Antibodies	>3 publications with GPX2 and Esophagus
Muscle Antibodies	>3 publications with GPX2 and Muscle