• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Serine/Threonine-Protein Kinase WNK4 (WNK4) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1453455

MBS1453455 is a recombinant protein targeting Wnk4. Also known as Recombinant Rat Serine/threonine-protein kinase WNK4 (Wnk4) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine/threonine-protein kinase WNK4 (Wnk4), Recombinant Protein
Full Product Name
Recombinant Rat Serine/threonine-protein kinase WNK4 (Wnk4) , partial
Product Gene Name
Wnk4 recombinant protein
Product Synonym Gene Name
Wnk4
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
132,833 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q7TPK6
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Wnk4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Wnk4. It may not necessarily be applicable to this product.

NCBI GI #
260166629
NCBI GeneID
287715
NCBI Accession #
NP_783169.2
UniProt Primary Accession #
Q7TPK6
UniProt Secondary Accession #
Q810H4; Q811R5
UniProt Related Accession #
Q7TPK6
GenBank Nucleotide #
NM_175579.3
NCBI Official Full Name
serine/threonine-protein kinase WNK4
NCBI Official Synonym Full Names
WNK lysine deficient protein kinase 4
NCBI Official Symbol
Wnk4
NCBI Official Synonym Symbols
Ac2-059; Prkwnk4
UniProt Protein Name
Serine/threonine-protein kinase WNK4
UniProt Synonym Protein Names
Protein kinase lysine-deficient 4
Protein Family
Probable serine/threonine-protein kinase
UniProt Gene Name
Wnk4
NCBI Protein Information
serine/threonine-protein kinase WNK4

NCBI Summary for Wnk4

mutation of the human homolog causes pseudohypoaldosteronism type II [RGD, Feb 2006]

UniProt Comments for Wnk4

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K+ channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition. Phosphorylates NEDD4L ().
Show more

Research Articles on Wnk4

1. in addition to SPAK and OSR1, WNK4 is able to anchor itself to the N-terminal domain of NKCC1 and to promote cotransporter activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Wnk4 recombinant protein

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with Wnk4 recombinant protein

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >170 publications with Wnk4 and Hypertension
 Pseudohypoaldosteronism Antibodies  >113 publications with Wnk4 and Pseudohypoaldosteronism
 Cardiovascular Diseases Antibodies  >93 publications with Wnk4 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >78 publications with Wnk4 and Kidney Diseases
 Disease Models, Animal Antibodies  >15 publications with Wnk4 and Disease Models, Animal
 Fibrosis Antibodies  >6 publications with Wnk4 and Fibrosis
 Nervous System Diseases Antibodies  >5 publications with Wnk4 and Nervous System Diseases
 Hyperplasia Antibodies  >4 publications with Wnk4 and Hyperplasia
 Brain Diseases Antibodies  >3 publications with Wnk4 and Brain Diseases
 Cerebral Infarction Antibodies  >3 publications with Wnk4 and Cerebral Infarction

Organs/Tissues associated with Wnk4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >117 publications with Wnk4 and Kidney
 Brain Antibodies  >10 publications with Wnk4 and Brain
 Lung Antibodies  >4 publications with Wnk4 and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000