ATOH1 Recombinant Protein – Cat# MBS1453457

Atonal Homolog 1 (ATOH1) Recombinant Protein

Name: ATOH1 Recombinant Protein; Atonal Homolog 1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS1453457
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1453457

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by… More details

$575 / 0.02 mg (Baculovirus) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Atonal homolog 1 (ATOH1), Recombinant Protein

Full Product Name

Recombinant Human Protein atonal homolog 1

Product Gene Name

ATOH1 recombinant protein

Product Synonym Names

Class A basic helix-loop-helix protein 14; bHLHa14; Helix-loop-helix protein hATH-1; hATH1

Sequence

MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

54.2 kDa

Sequence Positions

1-354aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

601461

3D Structure

ModBase 3D Structure for Q92858

Product Categories/Family for ATOH1 recombinant protein

Developmental Biology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for ATOH1 recombinant protein

Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis.Ben-Arie N., McCall A.E., Berkman S., Eichele G., Bellen H.J., Zoghbi H.Y.Hum. Mol. Genet. 5:1207-1216(1996)

Other Notes

Small volumes of ATOH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATOH1 purchase

MBS1453457 is a recombinant protein targeting ATOH1. Also known as Recombinant Human Protein atonal homolog 1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ATOH1. It may not necessarily be applicable to this product.

NCBI GI #

4885075

NCBI GeneID

474

NCBI Accession #

NP_005163.1

UniProt Primary Accession #

Q92858

UniProt Secondary Accession #

Q14CT9

UniProt Related Accession #

Q92858

GenBank Nucleotide #

NM_005172.1

NCBI Official Full Name

protein atonal homolog 1

NCBI Official Synonym Full Names

atonal bHLH transcription factor 1

NCBI Official Symbol

ATOH1

NCBI Official Synonym Symbols

ATH1; HATH1; MATH-1; bHLHa14

UniProt Protein Name

Protein atonal homolog 1

UniProt Synonym Protein Names

Class A basic helix-loop-helix protein 14; bHLHa14; Helix-loop-helix protein hATH-1; hATH1

Protein Family

Protein atonal

UniProt Gene Name

ATOH1

UniProt Synonym Gene Names

ATH1; BHLHA14; bHLHa14; hATH1

UniProt Entry Name

ATOH1_HUMAN

NCBI Protein Information

protein atonal homolog 1

NCBI Summary for ATOH1

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]

UniProt Comments for ATOH1

ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.

Protein type: DNA-binding; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: nucleus

Molecular Function: chromatin DNA binding; protein dimerization activity; transcription factor activity

Biological Process: auditory receptor cell fate determination; auditory receptor cell fate specification; axon guidance; central nervous system development; cerebral cortex development; inner ear morphogenesis; negative regulation of apoptosis; neuron migration; Notch signaling pathway; positive regulation of auditory receptor cell differentiation; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

Research Articles on ATOH1

1. Atoh1 protein stabilization induced both a cancer stem cell phenotype and a mucinous phenotype, resulting in the acquisition of chemoresistance in colorectal cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ATOH1 recombinant protein

Reference Product	PubMed Publications
SOX2 recombinant protein	>30 publications with ATOH1 and SOX2
SHH recombinant protein	>21 publications with ATOH1 and SHH
NOTCH1 recombinant protein	>19 publications with ATOH1 and NOTCH1
CTNNB1 recombinant protein	>16 publications with ATOH1 and CTNNB1
FGF8 recombinant protein	>10 publications with ATOH1 and FGF8
TCF4 recombinant protein	>4 publications with ATOH1 and TCF4
MUC5AC recombinant protein	>3 publications with ATOH1 and MUC5AC
ZIC1 recombinant protein	>2 publications with ATOH1 and ZIC1
TCF3 recombinant protein	>1 publications with ATOH1 and TCF3
TCF12 recombinant protein	>1 publications with ATOH1 and TCF12

Diseases associated with ATOH1 recombinant protein

Disease Name	Pubmed Publications
Medulloblastoma Antibodies	>35 publications with ATOH1 and Medulloblastoma
Brain Diseases Antibodies	>21 publications with ATOH1 and Brain Diseases
Disease Models, Animal Antibodies	>19 publications with ATOH1 and Disease Models, Animal
Inflammation Antibodies	>10 publications with ATOH1 and Inflammation
Necrosis Antibodies	>6 publications with ATOH1 and Necrosis
Hyperplasia Antibodies	>5 publications with ATOH1 and Hyperplasia
Lung Neoplasms Antibodies	>5 publications with ATOH1 and Lung Neoplasms
Lung Diseases Antibodies	>3 publications with ATOH1 and Lung Diseases
Nerve Degeneration Antibodies	>3 publications with ATOH1 and Nerve Degeneration
Atrophy Antibodies	>1 publications with ATOH1 and Atrophy

Organs/Tissues associated with ATOH1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>1 publications with ATOH1 and Mixed