Human HNRNPC Recombinant Protein – Cat# MBS145347

Heterogeneous Nuclear Ribonucleoprotein C (HNRNPC) Human Recombinant Protein

Name: HNRNPC Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145347
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145347

Description: HNRNPC produced in E Coli is a single, non-glycosylated polypeptide chain containing 313 amino acids (1-293a.a.) and having a molecular mass of 34.5kDa (Molecular weight on SDS-PAGE will appear higher). HNRNPC is fused to a 20 amino acid His-tag… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Heterogeneous Nuclear Ribonucleoprotein C (HNRNPC), Recombinant Protein

Full Product Name

Recombinant Human Heterogeneous Nuclear Ribonucleoprotein C

Product Gene Name

HNRNPC recombinant protein

Product Synonym Names

HNRNPC Human; Heterogeneous Nuclear Ribonucleoprotein C Human Recombinant; Heterogeneous Nuclear Ribonucleoprotein C (C1/C2); HNRPC; hnRNP C1/C2; hnRNPC; C1; C2; SNRPC; MGC104306; MGC105117; MGC117353; MGC131677

Sequence

MGSSHHH HHH SSGLVPRGSH MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSSFD LDYDFQRDYY DRMYSYPARV PPPPPIARAV VPSKRQRVSG NTSRRGKSGF NSKSGQRGSS KSGKLKGDDL QAIKKELTQI KQKVDSLLEN LEKIEKEQSK QAVEMKNDKS EEEQSSSSVK KDETNVKMES EGGADDSAEE GDLLDDDDNE DRGDDQLELI KDDEKEAEEG EDDRDSANGE DDS

Host

E Coli

Form/Format

The HNRNPC protein solution (0.25mg/ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 200mM NaCl, 5mM DTT and 30% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 85% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

27,822 Da

OMIM

164020

3D Structure

ModBase 3D Structure for P07910

Product Categories/Family for HNRNPC recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Heterogeneous Nuclear Ribonucleoprotein

Other Notes

Small volumes of HNRNPC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HNRNPC purchase

MBS145347 is a recombinant protein targeting HNRNPC. Also known as Recombinant Human Heterogeneous Nuclear Ribonucleoprotein C. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HNRNPC. It may not necessarily be applicable to this product.

NCBI GI #

117190192

NCBI GeneID

3183

NCBI Accession #

NP_001070910.1

UniProt Primary Accession #

P07910

UniProt Secondary Accession #

P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; D3DS19; D3DS22

UniProt Related Accession #

P07910

GenBank Nucleotide #

NM_001077442.1

NCBI Official Full Name

heterogeneous nuclear ribonucleoproteins C1/C2 isoform a

NCBI Official Synonym Full Names

heterogeneous nuclear ribonucleoprotein C (C1/C2)

NCBI Official Symbol

HNRNPC

NCBI Official Synonym Symbols

C1; C2; HNRNP; HNRPC; SNRPC

UniProt Protein Name

Heterogeneous nuclear ribonucleoproteins C1/C2

Protein Family

Heterogeneous nuclear ribonucleoprotein

UniProt Gene Name

HNRNPC

UniProt Synonym Gene Names

HNRPC; hnRNP C1/C2

UniProt Entry Name

HNRPC_HUMAN

NCBI Protein Information

heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein

NCBI Summary for HNRNPC

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for HNRNPC

hnRNP C1/C2: a heterogeneous nuclear ribonucleoprotein. May play a role in ribonucleosome assembly by neutralizing basic proteins such as A and B core hnRNP. Contains 1 RNA recognition motif (RRM) domain. Two alternatively spliced isoforms have been described.

Protein type: RNA-binding; Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; spliceosome; protein complex; membrane; nuclear chromatin; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; nucleosomal DNA binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; poly(U) binding

Biological Process: osteoblast differentiation; nuclear mRNA splicing, via spliceosome; RNA splicing; ATP-dependent chromatin remodeling; gene expression

Research Articles on HNRNPC

1. PTBP1 and hnRNP C repress exon 3 inclusion, and that downregulation of PTBP1 inhibited BIM-mediated apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HNRNPC recombinant protein

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies	Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
Regulation Of Telomerase Pathway antibodies	Regulation Of Telomerase Pathway Diagram
Spliceosome Pathway antibodies	Spliceosome Pathway Diagram
Spliceosome Pathway antibodies	Spliceosome Pathway Diagram
MRNA Splicing Pathway antibodies	MRNA Splicing Pathway Diagram
MRNA Splicing - Major Pathway antibodies	MRNA Splicing - Major Pathway Diagram
MRNA Processing Pathway antibodies	MRNA Processing Pathway Diagram

Diseases associated with HNRNPC recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>3 publications with HNRNPC and Carcinoma
Lung Diseases Antibodies	>3 publications with HNRNPC and Lung Diseases
Lung Neoplasms Antibodies	>3 publications with HNRNPC and Lung Neoplasms
Death Antibodies	>2 publications with HNRNPC and Death
Breast Neoplasms Antibodies	>2 publications with HNRNPC and Breast Neoplasms
Inflammation Antibodies	>2 publications with HNRNPC and Inflammation
Neoplasm Metastasis Antibodies	>1 publications with HNRNPC and Neoplasm Metastasis
Carcinoma, Hepatocellular Antibodies	>1 publications with HNRNPC and Carcinoma, Hepatocellular
Disease Models, Animal Antibodies	>1 publications with HNRNPC and Disease Models, Animal
Weight Loss Antibodies	>1 publications with HNRNPC and Weight Loss

Organs/Tissues associated with HNRNPC recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>7 publications with HNRNPC and Lung
Liver Antibodies	>5 publications with HNRNPC and Liver
Brain Antibodies	>4 publications with HNRNPC and Brain
Ovary Antibodies	>2 publications with HNRNPC and Ovary
Kidney Antibodies	>2 publications with HNRNPC and Kidney
Embryonic Tissue Antibodies	>2 publications with HNRNPC and Embryonic Tissue
Nerve Antibodies	>2 publications with HNRNPC and Nerve
Bone Antibodies	>1 publications with HNRNPC and Bone
Lymph Antibodies	>1 publications with HNRNPC and Lymph
Blood Antibodies	>1 publications with HNRNPC and Blood