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Fibroblast Growth Factor-15 (mFGF-15) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145349

Description: FGF-15 Protein is 23.78 kDa protein containing 203 amino acid residues including a 10 a.a. N-Terminal His-tag.Introduction: FGF-15 takes part in the suppression of bile acid biosynthesis by down-regulation of CYP7A1 expression. FGF-15 is… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Fibroblast Growth Factor-15 (mFGF-15), Recombinant Protein
Full Product Name
Recombinant Mouse Fibroblast Growth Factor-15
Product Gene Name
mFGF-15 recombinant protein
Product Synonym Names
FGF 15 Mouse; Fibroblast Growth Factor-15 Mouse Recombinant; Fibroblast Growth Factor 15; FGF19
Sequence
MKHHHHH HAS RPLAQQSQSV SDEDPLFLYG WGKITRLQYL YSAGPYVSNC FLRIRSDGSV DCEEDQNERN LLEFRAVALK TIAIKDVSSV RYLCMSADGK IYGLIRYSEE DCTFREEMDC LGYNQYRSMK HHLHIIFIQA KPREQLQDQK PSNFIPVFHR SFFETGDQLR SKMFSLPLES DSMDPFRMVE DVDHLVKSPS FQK.
Host
E Coli
Form/Format
FGF-15 was filtered (0.4 um) and lyophilized from 0.5mg/ml supplied in 20mM TRIS and 20mM NaCl and 1mM DTT, pH 8.0. 
Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Purity as determined by densitometric image analysis is greater than 90%.
Preparation and Storage
Store lyophilized FGF-15 at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted FGF-15 can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
Molecular Weight
25,236 Da
3D Structure
ModBase 3D Structure for O35622
Solubility
It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.

Product Categories/Family for mFGF-15 recombinant protein

Cytokines and Growth Factors; Growth Factors; Fibroblast Growth Factor

Other Notes

Small volumes of mFGF-15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mFGF-15 purchase

MBS145349 is a recombinant protein targeting mFGF-15. Also known as Recombinant Mouse Fibroblast Growth Factor-15. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mFGF-15. It may not necessarily be applicable to this product.

NCBI GI #
6679777
NCBI GeneID
14170
NCBI Accession #
NP_032029.1
UniProt Primary Accession #
O35622
UniProt Related Accession #
O35622
GenBank Nucleotide #
NM_008003.2
NCBI Official Full Name
fibroblast growth factor 15
NCBI Official Synonym Full Names
fibroblast growth factor 15
NCBI Official Symbol
Fgf15
NCBI Official Synonym Symbols
FGF19
UniProt Protein Name
Fibroblast growth factor 15
Protein Family
Fibroblast growth factor
UniProt Gene Name
Fgf15
UniProt Synonym Gene Names
FGF-15
UniProt Entry Name
FGF15_MOUSE
NCBI Protein Information
fibroblast growth factor 15; FGF-15

UniProt Comments for mFGF-15

FGF19: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Cell development/differentiation

Cellular Component: extracellular region

Molecular Function: protein binding; growth factor activity; fibroblast growth factor receptor binding; receptor binding

Biological Process: positive regulation of glucose import; fibroblast growth factor receptor signaling pathway; heart development; positive regulation of cell proliferation; positive regulation of JNK cascade; positive regulation of protein amino acid phosphorylation; neural crest cell migration
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Research Articles on mFGF-15

1. results suggest that FGF15 deficiency severely impairs liver regeneration in mice after PHx. The underlying mechanism is likely the result of disrupted bile acid homeostasis and impaired priming of hepatocyte proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with mFGF-15 recombinant protein

 Reference Product  PubMed Publications
 Cyp7a1 recombinant protein  >45 publications with mFGF-15 and Cyp7a1
 Fgfr4 recombinant protein  >24 publications with mFGF-15 and Fgfr4
 Fgf8 recombinant protein  >12 publications with mFGF-15 and Fgf8
 Fgfr1 recombinant protein  >5 publications with mFGF-15 and Fgfr1
 Fgf17 recombinant protein  >4 publications with mFGF-15 and Fgf17
 Fgfr2 recombinant protein  >2 publications with mFGF-15 and Fgfr2
 Klb recombinant protein  >2 publications with mFGF-15 and Klb
 Fgf6 recombinant protein  >1 publications with mFGF-15 and Fgf6
 Fgfr3 recombinant protein  >1 publications with mFGF-15 and Fgfr3

Pathways associated with mFGF-15 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 ESC Pluripotency Pathways antibodies  ESC Pluripotency Pathways Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram

Diseases associated with mFGF-15 recombinant protein

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >9 publications with mFGF-15 and Fatty Liver
 Inflammation Antibodies  >9 publications with mFGF-15 and Inflammation
 Disease Models, Animal Antibodies  >8 publications with mFGF-15 and Disease Models, Animal
 Insulin Resistance Antibodies  >7 publications with mFGF-15 and Insulin Resistance
 Cholestasis Antibodies  >5 publications with mFGF-15 and Cholestasis
 Liver Neoplasms Antibodies  >4 publications with mFGF-15 and Liver Neoplasms
 Weight Gain Antibodies  >3 publications with mFGF-15 and Weight Gain
 Fibrosis Antibodies  >3 publications with mFGF-15 and Fibrosis
 Necrosis Antibodies  >3 publications with mFGF-15 and Necrosis
 Drug-Induced Liver Injury Antibodies  >3 publications with mFGF-15 and Drug-Induced Liver Injury

Organs/Tissues associated with mFGF-15 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with mFGF-15 and Brain
 Embryonic Tissue Antibodies  >11 publications with mFGF-15 and Embryonic Tissue
 Eye Antibodies  >7 publications with mFGF-15 and Eye
 Inner Ear Antibodies  >2 publications with mFGF-15 and Inner Ear
 Spinal Cord Antibodies  >2 publications with mFGF-15 and Spinal Cord
 Lung Antibodies  >1 publications with mFGF-15 and Lung
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