Human LCMT1 Recombinant Protein – Cat# MBS145387

Leucine Carboxyl Methyltransferase 1 (LCMT1) Human Recombinant Protein

Name: LCMT1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145387
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145387

Description: LCMT1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 358 amino acids (1-334) and having a molecular mass of 41kDa.LCMT1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Leucine Carboxyl Methyltransferase 1 (LCMT1), Recombinant Protein

Full Product Name

Recombinant Human Leucine Carboxyl Methyltransferase 1

Product Gene Name

LCMT1 recombinant protein

Product Synonym Names

LCMT1 Human; Leucine Carboxyl Methyltransferase 1 Human Recombinant; Leucine carboxyl methyltransferase 1; Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; LCMT1; LCMT; PPMT1; CGI-68

Sequence

MGSSHHH HHH SSGLVPRGSH MGSHMA TRQR ESSITSCCST SSCDADDEGV RGTCEDASLC KRFAVSIGYW HDPYIQHFVR LSKERKAPEI NRGYFARVHG VSQLIKAFLR KTECHCQIVN LGAGMDTTFW RLKDEDLLPS KYFEVDFPMI VTRKLHSIKC KPPLSSPILE LHSEDTLQMD GHILDSKRYA VIGADLRDLS ELEEKLKKCN MNTQLPTLLI AECVLVYMTP EQSANLLKWA ANSFERAMFI NYEQVNMGDR FGQIMIENLR RRQCDLAGVE TCKSLESQKE RLLSNGWETA SAVDMMELYN RLPRAEVSRI ESLEFLDEME LLEQLMRHYC LCWATKGGNE LGLKEITY.< /u>

Host

E Coli

Form/Format

The LCMT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.15M NaCl.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Molecular Weight

32,172 Da

OMIM

610286

3D Structure

ModBase 3D Structure for Q9UIC8

Product Categories/Family for LCMT1 recombinant protein

Enzymes; Transferase

Other Notes

Small volumes of LCMT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LCMT1 purchase

MBS145387 is a recombinant protein targeting LCMT1. Also known as Recombinant Human Leucine Carboxyl Methyltransferase 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LCMT1. It may not necessarily be applicable to this product.

NCBI GI #

74048545

NCBI GeneID

51451

NCBI Accession #

NP_001027563.1

UniProt Primary Accession #

Q9UIC8

UniProt Secondary Accession #

Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9Y378; A6NL89; A8K770

UniProt Related Accession #

Q9UIC8

GenBank Nucleotide #

NM_001032391.1

NCBI Official Full Name

leucine carboxyl methyltransferase 1 isoform b

NCBI Official Synonym Full Names

leucine carboxyl methyltransferase 1

NCBI Official Symbol

LCMT1

NCBI Official Synonym Symbols

LCMT; PPMT1; CGI-68

UniProt Protein Name

Leucine carboxyl methyltransferase 1

UniProt Synonym Protein Names

Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

Protein Family

Leucine carboxyl methyltransferase

UniProt Gene Name

LCMT1

UniProt Synonym Gene Names

LCMT

UniProt Entry Name

LCMT1_HUMAN

NCBI Protein Information

leucine carboxyl methyltransferase 1; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; protein phosphatase methyltransferase 1; protein-leucine O-methyltransferase

NCBI Summary for LCMT1

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]

UniProt Comments for LCMT1

LCMT1: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine; EC 2.1.1.233; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acid

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: cytosol

Molecular Function: protein binding; C-terminal protein carboxyl methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; protein modification process; negative regulation of protein complex assembly

Research Articles on LCMT1

1. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LCMT1 recombinant protein

Reference Product	PubMed Publications
PPP2CA recombinant protein	>9 publications with LCMT1 and PPP2CA
PPP2CB recombinant protein	>8 publications with LCMT1 and PPP2CB
PPP2R4 recombinant protein	>1 publications with LCMT1 and PPP2R4
PPP2R2A recombinant protein	>1 publications with LCMT1 and PPP2R2A

Organs/Tissues associated with LCMT1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with LCMT1 and Brain
Vascular Antibodies	>1 publications with LCMT1 and Vascular
Embryonic Tissue Antibodies	>1 publications with LCMT1 and Embryonic Tissue
Pancreas Antibodies	>1 publications with LCMT1 and Pancreas