Human NT5M Recombinant Protein – Cat# MBS145401

5',3'-Nucleotidase (NT5M) Human Recombinant Protein

Name: NT5M Recombinant Protein; 5',3'-Nucleotidase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145401
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145401

Description: NT5M Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 218 amino acids (32-228 a.a.) and having a molecular mass of 25.1kDa.NT5M is fused to a 21 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

5',3'-Nucleotidase (NT5M), Recombinant Protein

Full Product Name

Recombinant Human 5',3'-Nucleotidase, Mitochondrial

Product Gene Name

NT5M recombinant protein

Product Synonym Names

NT5M Human; 5',3'-Nucleotidase, Mitochondrial Human Recombinant; 5'(3')-deoxyribonucleotidase mitochondrial; 5'; 3'-nucleotidase; mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2; NT5M; DNT2

Sequence

MGSSHHH HHH SSGLVPRGSH MGGRAL RVLV DMDGVLADFE GGFLRKFRAR FPDQPFIALE DRRGFWVSEQ YGRLRPGLSE KAISIWESKN FFFELEPLPG AVEAVKEMAS LQNTDVFICT SPIKMFKYCP YEKYAWVEKY FGPDFLEQIV LTRDKTVVSA DLLIDDRPDI TGAEPTPSWE HVLFTACHNQ HLQLQPPRRR LHSWADDWKA ILDSKRPC

Host

E Coli

Form/Format

NT5M protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Sterile Filtered clear solution.

Purity/Purification

Greater than 95% as determined by SDS-PAGE.

Molecular Weight

25,862 Da

OMIM

605292

3D Structure

ModBase 3D Structure for Q9NPB1

Product Categories/Family for NT5M recombinant protein

Enzymes; Nucleotidase

Other Notes

Small volumes of NT5M recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NT5M purchase

MBS145401 is a recombinant protein targeting NT5M. Also known as Recombinant Human 5',3'-Nucleotidase, Mitochondrial. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NT5M. It may not necessarily be applicable to this product.

NCBI GI #

9910372

NCBI GeneID

56953

NCBI Accession #

NP_064586.1

UniProt Primary Accession #

Q9NPB1

UniProt Related Accession #

Q9NPB1

GenBank Nucleotide #

NM_020201.3

NCBI Official Full Name

5'(3')-deoxyribonucleotidase, mitochondrial

NCBI Official Synonym Full Names

5',3'-nucleotidase, mitochondrial

NCBI Official Symbol

NT5M

NCBI Official Synonym Symbols

mdN; dNT2; dNT-2

UniProt Protein Name

5'(3')-deoxyribonucleotidase, mitochondrial

UniProt Synonym Protein Names

Deoxy-5'-nucleotidase 2; dNT-2

Protein Family

5'-nucleotidase

UniProt Gene Name

NT5M

UniProt Synonym Gene Names

DNT2; 5',3'-nucleotidase, mitochondrial; dNT-2

UniProt Entry Name

NT5M_HUMAN

NCBI Protein Information

5'(3')-deoxyribonucleotidase, mitochondrial; 5'(3')-deoxyribonucleotidase, mitochondrial; 5' nucleotidase, mitochondrial; 5(3)-deoxyribonucleotidase; deoxy-5'-nucleotidase 2; mitochondrial 5' nucleotidase

NCBI Summary for NT5M

This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

UniProt Comments for NT5M

NT5M: Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. Belongs to the 5'(3')-deoxyribonucleotidase family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - pyrimidine; Mitochondrial; EC 3.1.3.-; Nucleotide Metabolism - purine; Phosphatase (non-protein); DNA replication

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: 5'-nucleotidase activity; metal ion binding; nucleotide binding; nucleotidase activity

Biological Process: pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine deoxyribonucleotide catabolic process; dUMP catabolic process; DNA replication

Research Articles on NT5M

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NT5M recombinant protein

Products by Pathway	Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Nicotinate And Nicotinamide Metabolism Pathway antibodies	Nicotinate And Nicotinamide Metabolism Pathway Diagram
Nicotinate And Nicotinamide Metabolism Pathway antibodies	Nicotinate And Nicotinamide Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Pyrimidine Catabolism Pathway antibodies	Pyrimidine Catabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram

Diseases associated with NT5M recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>1 publications with NT5M and Liver Diseases
Inflammation Antibodies	>1 publications with NT5M and Inflammation

Organs/Tissues associated with NT5M recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with NT5M and Blood
Muscle Antibodies	>1 publications with NT5M and Muscle