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Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1 (ENPP1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1454393

This gene is a member of the ecto-nucleotide pyrophosphatasephosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1), Recombinant Protein
Full Product Name
Recombinant Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1) , partial
Product Gene Name
Enpp1 recombinant protein
Product Synonym Gene Name
Enpp1
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
102,843 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q924C3
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Enpp1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Enpp1 purchase

MBS1454393 is a recombinant protein targeting Enpp1. Also known as Recombinant Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Enpp1. It may not necessarily be applicable to this product.

NCBI GI #
16758300
NCBI GeneID
85496
NCBI Accession #
NP_445987.1
UniProt Primary Accession #
Q924C3
UniProt Secondary Accession #
Q91XQ3; Q920C8
UniProt Related Accession #
Q924C3
GenBank Nucleotide #
NM_053535.1
NCBI Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase family member 1
NCBI Official Synonym Full Names
ectonucleotide pyrophosphatase/phosphodiesterase 1
NCBI Official Symbol
Enpp1
NCBI Official Synonym Symbols
Pc1; Npps
UniProt Protein Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
UniProt Synonym Protein Names
Nucleotide diphosphataseCurated
Protein Family
Ectonucleotide pyrophosphatase/phosphodiesterase family
UniProt Gene Name
Enpp1
UniProt Synonym Gene Names
Npps; Pc1; Pdnp1; NPPase
NCBI Protein Information
ectonucleotide pyrophosphatase/phosphodiesterase family member 1

NCBI Summary for Enpp1

mutation of the human homolog is detected in patients with idiopathic infantile arterial calcification [RGD, Feb 2006]

UniProt Comments for Enpp1

By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
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Research Articles on Enpp1

1. Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Enpp1 recombinant protein

 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with Enpp1 recombinant protein

 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >54 publications with Enpp1 and Diabetes Mellitus, Type 2
 Obesity Antibodies  >44 publications with Enpp1 and Obesity
 Cardiovascular Diseases Antibodies  >28 publications with Enpp1 and Cardiovascular Diseases
 Arterial calcification of infancy Antibodies  >18 publications with Enpp1 and Arterial calcification of infancy
 Myocardial Ischemia Antibodies  >14 publications with Enpp1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >12 publications with Enpp1 and Kidney Diseases
 Liver Diseases Antibodies  >5 publications with Enpp1 and Liver Diseases
 Hypertension Antibodies  >5 publications with Enpp1 and Hypertension
 Fibrosis Antibodies  >4 publications with Enpp1 and Fibrosis
 Ossification of Posterior Longitudinal Ligament Antibodies  >3 publications with Enpp1 and Ossification of Posterior Longitudinal Ligament

Organs/Tissues associated with Enpp1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >13 publications with Enpp1 and Muscle
 Connective Tissue Antibodies  >9 publications with Enpp1 and Connective Tissue
 Embryonic Tissue Antibodies  >3 publications with Enpp1 and Embryonic Tissue
 Pancreas Antibodies  >2 publications with Enpp1 and Pancreas
 Ovary Antibodies  >2 publications with Enpp1 and Ovary
 Placenta Antibodies  >1 publications with Enpp1 and Placenta
 Colon Antibodies  >1 publications with Enpp1 and Colon
 Brain Antibodies  >1 publications with Enpp1 and Brain
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