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Transcription Factor B2 (TFB2M) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145466

Description: TFB2M Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (20-396 a.a) and having a molecular mass of 45.8kDa.TFB2M is fused to a 24 amino acid His-tag at N-terminus & purified by… More details

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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Transcription Factor B2 (TFB2M), Recombinant Protein
Full Product Name
Recombinant Human Transcription Factor B2, Mitochondrial
Product Gene Name
TFB2M recombinant protein
Product Synonym Names
TFB2M Human; Transcription Factor B2, Mitochondrial Human Recombinant; Dimethyladenosine transferase 2 mitochondrial; Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N'; N'-adenosyl(rRNA) dimethyltransferase 2; TFB2M; NS5ATP5; Hkp1
Sequence
MGSSHHH HHH SSGLVPRGSH MGSMAG RFCI LGSEAATRKH LPARNHCGLS DSSPQLWPEP DFRNPPRKAS KASLDFKRYV TDRRLAETLA QIYLGKPSRP PHLLLECNPG PGILTQALLE AGAKVVALES DKTFIPHLES LGKNLDGKLR VIHCDFFKLD PRSGGVIKPP AMSSRGLFKN LGIEAVPWTA DIPLKVVGMF PSRGEKRALW KLAYDLYSCT SIYKFGRIEV NMFIGEKEFQ KLMADPGNPD LYHVLSVIWQ LACEIKVLHM EPWSSFDIYT RKGPLENPKR RELLDQLQQK LYLIQMIPRQ NLFTKNLTPM NYNIFFHLLK HCFGRRSATV IDHLRSLTPL DARDILMQIG KQEDEKVVNM HPQDFKTLFE TIERSKDCAY KWLYDETLED R.
Host
E Coli
Form/Format
TFB2M protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
45,349 Da
OMIM
607055
3D Structure
ModBase 3D Structure for Q9H5Q4

Product Categories/Family for TFB2M recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of TFB2M recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFB2M purchase

MBS145466 is a recombinant protein targeting TFB2M. Also known as Recombinant Human Transcription Factor B2, Mitochondrial. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TFB2M. It may not necessarily be applicable to this product.

NCBI GI #
11641289
NCBI GeneID
64216
NCBI Accession #
NP_071761.1
UniProt Primary Accession #
Q9H5Q4
UniProt Secondary Accession #
Q9H626
UniProt Related Accession #
Q9H5Q4
GenBank Nucleotide #
NM_022366.2
NCBI Official Full Name
dimethyladenosine transferase 2, mitochondrial
NCBI Official Synonym Full Names
transcription factor B2, mitochondrial
NCBI Official Symbol
TFB2M
NCBI Official Synonym Symbols
Hkp1; mtTFB2
UniProt Protein Name
Dimethyladenosine transferase 2, mitochondrial
UniProt Synonym Protein Names
Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
Protein Family
Dimethyladenosine transferase
UniProt Gene Name
TFB2M
UniProt Synonym Gene Names
NS5ATP5; HCV NS5A-transactivated protein 5; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2
UniProt Entry Name
TFB2M_HUMAN
NCBI Protein Information
dimethyladenosine transferase 2, mitochondrial; HCV NS5A-transactivated protein 5; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; h-mtTFB; h-mtTFB2; hTFB2M; hepatitis C virus NS5A-transactivated protein 5; mitochondrial 12S rRNA dimethylase 2; mitochondrial transcription factor B2

UniProt Comments for TFB2M

TFB2M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

Protein type: EC 2.1.1.-; Methyltransferase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: mitochondrial matrix

Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity; transcription cofactor activity

Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription, DNA-dependent; organelle organization and biogenesis; rRNA methylation; gene expression; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter
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Research Articles on TFB2M

1. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TFB2M recombinant protein

 Reference Product  PubMed Publications
 TFAM recombinant protein  >41 publications with TFB2M and TFAM
 POLRMT recombinant protein  >15 publications with TFB2M and POLRMT
 ATP2A2 recombinant protein  >1 publications with TFB2M and ATP2A2

Pathways associated with TFB2M recombinant protein

 Products by Pathway  Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Mitochondrial Gene Expression Pathway antibodies  Mitochondrial Gene Expression Pathway Diagram
 Mitochondrial Biogenesis Pathway antibodies  Mitochondrial Biogenesis Pathway Diagram
 Mitochondrial Transcription Initiation Pathway antibodies  Mitochondrial Transcription Initiation Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 Transcription From Mitochondrial Promoters Pathway antibodies  Transcription From Mitochondrial Promoters Pathway Diagram
 Transcriptional Activation Of Mitochondrial Biogenesis Pathway antibodies  Transcriptional Activation Of Mitochondrial Biogenesis Pathway Diagram

Diseases associated with TFB2M recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4 publications with TFB2M and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with TFB2M and Hypertrophy
 Fatty Liver, Alcoholic Antibodies  >1 publications with TFB2M and Fatty Liver, Alcoholic
 Liver Diseases Antibodies  >1 publications with TFB2M and Liver Diseases
 Fatty Liver Antibodies  >1 publications with TFB2M and Fatty Liver
 Inflammation Antibodies  >1 publications with TFB2M and Inflammation

Organs/Tissues associated with TFB2M recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >10 publications with TFB2M and Muscle
 Blood Antibodies  >5 publications with TFB2M and Blood
 Brain Antibodies  >3 publications with TFB2M and Brain
 Heart Antibodies  >2 publications with TFB2M and Heart
 Liver Antibodies  >2 publications with TFB2M and Liver
 Mammary Gland Antibodies  >1 publications with TFB2M and Mammary Gland
 Uterus Antibodies  >1 publications with TFB2M and Uterus
 Embryonic Tissue Antibodies  >1 publications with TFB2M and Embryonic Tissue
 Spleen Antibodies  >1 publications with TFB2M and Spleen
 Connective Tissue Antibodies  >1 publications with TFB2M and Connective Tissue
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