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Ribonuclease 3 (RNASE3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145484

Description: RNASE3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 171 amino acids (28-160) and having a molecular mass of 19.9kDa. RNASE3 is fused to a 38 amino acid His-tag at N-terminus & purified by… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ribonuclease 3 (RNASE3), Recombinant Protein
Full Product Name
Recombinant Human Ribonuclease 3
Product Gene Name
RNASE3 recombinant protein
Product Synonym Names
RNASE3 Human; Ribonuclease 3 Human Recombinant; ECP; RNS3; Ribonuclease 3; Eosinophil cationic protein; RNASE3; RNASE3
Sequence
MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRP PQFTRAQWFA IQHISLNPPR CTIAMRAINN YRWRCKNQNT FLRTTFANVV NVCGNQSIRC PHNRTLNNCH RSRFRVPLLH CDLINPGAQN ISNCRYADRP GRRFYVVACD NRDPRDSPRY PVVPVHLDTT I
Host
E Coli
Form/Format
The RNASE3 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
18,385 Da
OMIM
131398
3D Structure
ModBase 3D Structure for P12724

Product Categories/Family for RNASE3 recombinant protein

Enzymes; Nuclease

Other Notes

Small volumes of RNASE3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RNASE3 purchase

MBS145484 is a recombinant protein targeting RNASE3. Also known as Recombinant Human Ribonuclease 3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RNASE3. It may not necessarily be applicable to this product.

NCBI GI #
45243507
NCBI GeneID
6037
NCBI Accession #
NP_002926.2
UniProt Primary Accession #
P12724
UniProt Secondary Accession #
Q4VBC1; Q8WTP7; Q8WZ62; Q9GZN9
UniProt Related Accession #
P12724
GenBank Nucleotide #
NM_002935.2
NCBI Official Full Name
eosinophil cationic protein
NCBI Official Synonym Full Names
ribonuclease, RNase A family, 3
NCBI Official Symbol
RNASE3
NCBI Official Synonym Symbols
ECP; RNS3
UniProt Protein Name
Eosinophil cationic protein
UniProt Synonym Protein Names
Ribonuclease 3; RNase 3
Protein Family
Eosinophil cationic protein
UniProt Gene Name
RNASE3
UniProt Synonym Gene Names
ECP; RNS3; ECP; RNase 3
UniProt Entry Name
ECP_HUMAN
NCBI Protein Information
eosinophil cationic protein; RNase 3; cytotoxic ribonuclease; ribonuclease 3

NCBI Summary for RNASE3

The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]

UniProt Comments for RNASE3

RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. Belongs to the pancreatic ribonuclease family.

Protein type: Secreted, signal peptide; Secreted; Ribonuclease; EC 3.1.27.-

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: nucleic acid binding; endonuclease activity; ribonuclease activity

Biological Process: defense response to Gram-positive bacterium; innate immune response in mucosa; RNA catabolic process; antibacterial humoral response
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Research Articles on RNASE3

1. eosinophil cationic protein levels can be used to diagnosis atopic dermatitis but cannot distinguish between intrinsic and extrinsic disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RNASE3 recombinant protein

 Reference Product  PubMed Publications
 RNASE2 recombinant protein  >5 publications with RNASE3 and RNASE2
 MPO recombinant protein  >5 publications with RNASE3 and MPO
 EPX recombinant protein  >4 publications with RNASE3 and EPX
 IL5 recombinant protein  >1 publications with RNASE3 and IL5

Pathways associated with RNASE3 recombinant protein

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram

Diseases associated with RNASE3 recombinant protein

 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >74 publications with RNASE3 and Hypersensitivity
 Respiratory Tract Diseases Antibodies  >65 publications with RNASE3 and Respiratory Tract Diseases
 Respiratory Hypersensitivity Antibodies  >58 publications with RNASE3 and Respiratory Hypersensitivity
 Asthma Antibodies  >56 publications with RNASE3 and Asthma
 Lung Diseases Antibodies  >49 publications with RNASE3 and Lung Diseases
 Lung Diseases, Obstructive Antibodies  >47 publications with RNASE3 and Lung Diseases, Obstructive
 Inflammation Antibodies  >44 publications with RNASE3 and Inflammation
 Rhinitis Antibodies  >21 publications with RNASE3 and Rhinitis
 Eosinophilia Antibodies  >18 publications with RNASE3 and Eosinophilia
 Rhinitis, Allergic, Seasonal Antibodies  >13 publications with RNASE3 and Rhinitis, Allergic, Seasonal

Organs/Tissues associated with RNASE3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >88 publications with RNASE3 and Blood
 Eye Antibodies  >2 publications with RNASE3 and Eye
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