Human LAG-1 Recombinant Protein – Cat# MBS145491

LAG-1 Human Recombinant Protein

Name: LAG-1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145491
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145491

Introduction: CCL4L1 (C-C motif chemokine 4-like) is a member of to intercrine beta (chemokine CC) family. The CCL4L1 protein is similar to CCL4 which inhibits HIV replication in peripheral blood monocytes which express CCR5. More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LAG-1, Recombinant Protein

Full Product Name

Recombinant Human LAG-1 (CCL4L1)

Product Gene Name

LAG-1 recombinant protein

Product Synonym Names

LAG-1 Human; LAG-1 Human Recombinant (CCL4L1); C-C motif chemokine 4-like; Lymphocyte activation gene 1 protein; LAG-1; Macrophage inflammatory protein 1-beta; MIP-1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like; CCL4L1; CCL4L; LAG1; SCYA4L1; CCL4L2; SCYA4L2; AT744.2

Sequence

APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN

Host

E Coli

Form/Format

LAG-1 was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized LAG-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL4L1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Molecular Weight

11,008 Da

OMIM

603782

3D Structure

ModBase 3D Structure for Q8NHW4

Solubility

It is recommended to reconstitute the lyophilized LAG-1 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for LAG-1 recombinant protein

Chemokines; MIP

Other Notes

Small volumes of LAG-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAG-1 purchase

MBS145491 is a recombinant protein targeting LAG-1. Also known as Recombinant Human LAG-1 (CCL4L1). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LAG-1. It may not necessarily be applicable to this product.

NCBI GI #

612400620

NCBI GeneID

9560

NCBI Accession #

NP_001278397.1

UniProt Primary Accession #

Q8NHW4

UniProt Secondary Accession #

Q50EM1; Q50EM2; Q50EM3; Q50EM4; Q50EM5; Q50EM6; Q50EM7; Q50EM8; Q569J2; B2RUZ3; B7ZMA8

GenBank Nucleotide #

NM_001291468.1

NCBI Official Full Name

C-C motif chemokine 4-like isoform 1

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 4-like 2

NCBI Official Symbol

CCL4L2

NCBI Official Synonym Symbols

CCL4L; SCYA4L; AT744.2; SCYQ4L2

UniProt Protein Name

C-C motif chemokine 4-like

UniProt Synonym Protein Names

Lymphocyte activation gene 1 protein; LAG-1; Macrophage inflammatory protein 1-beta; MIP-1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL4L1

UniProt Synonym Gene Names

CCL4L; LAG1; SCYA4L1; LAG-1; MIP-1-beta

UniProt Entry Name

CC4L_HUMAN

NCBI Protein Information

C-C motif chemokine 4-like; MIP-1-beta; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1b2; monocyte adherence-induced protein 5-alpha; small inducible cytokine A4-like

NCBI Summary for LAG-1

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]

UniProt Comments for LAG-1

CCL4L1: Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. Belongs to the intercrine beta (chemokine CC) family. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Research Articles on LAG-1

1. PCR results show that lower copy numbers of CCL4L2 are observed in the Caucasian population nd higher copy numbers are observed in the Black population of South Africa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with LAG-1 recombinant protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Toll-like Receptor Signaling Pathway antibodies	Toll-like Receptor Signaling Pathway Diagram

Diseases associated with LAG-1 recombinant protein

Disease Name	Pubmed Publications
Disease Susceptibility Antibodies	>1 publications with LAG-1 and Disease Susceptibility

Organs/Tissues associated with LAG-1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with LAG-1 and Blood
Kidney Antibodies	>1 publications with LAG-1 and Kidney