Ras Homolog Gene Family Member Q (RHOQ) Human Recombinant Protein

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

RHOQ: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. Belongs to the small GTPase superfamily. Rho family.

Protein type: G protein, monomeric; G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: plasma membrane; actin filament; cytosol; lipid raft

Molecular Function: GTPase activity; GTP binding; GBD domain binding; profilin binding

Biological Process: positive regulation of filopodium formation; regulation of cell shape; positive regulation of glucose import; regulation of small GTPase mediated signal transduction; cellular response to insulin stimulus; metabolic process; regulation of actin cytoskeleton organization and biogenesis; small GTPase mediated signal transduction; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cortical actin cytoskeleton organization and biogenesis