Human NUDT4 Recombinant Protein – Cat# MBS145555

Nudix Type Motif 4 (NUDT4) Human Recombinant Protein

Name: NUDT4 Recombinant Protein; Nudix Type Motif 4; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145555
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145555

Description: NUDT4 produced in E Coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (1-180 a.a) and having a molecular mass of 22.7kDa. NUDT4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nudix Type Motif 4 (NUDT4), Recombinant Protein

Full Product Name

Recombinant Human Nudix Type Motif 4

Product Gene Name

NUDT4 recombinant protein

Product Synonym Names

NUDT4 Human; Nudix Type Motif 4 Human Recombinant; Diphosphoinositol polyphosphate phosphohydrolase 2; DIPP-2; EC 3.6.1.52; Diadenosine 5'; 5'''-P1; P6-hexaphosphate hydrolase 2; Nucleoside diphosphate-linked moiety X motif 4; NUDT4; DIPP2; KIAA0487; HDCMB47P; DIPP2beta; DIPP2alpha

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMMK FKPN QTRTYDREGF KKRAACLCFR SEQEDEVLLV SSSRYPDQWI VPGGGMEPEE EPGGAAVREV YEEAGVKGKL GRLLGIFENQ DRKHRTYVYV LTVTEILEDW EDSVNIGRKR EWFKVEDAIK VLQCHKPVHA EYLEKLKLGC SPANGNSTVP SLPDNNALFV TAAQTSGLPS SVR.

Host

E Coli

Form/Format

NUDT4 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

14,395 Da

OMIM

609229

3D Structure

ModBase 3D Structure for Q9NZJ9

Product Categories/Family for NUDT4 recombinant protein

Enzymes; Nudix Type Motif

Other Notes

Small volumes of NUDT4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NUDT4 purchase

MBS145555 is a recombinant protein targeting NUDT4. Also known as Recombinant Human Nudix Type Motif 4. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NUDT4. It may not necessarily be applicable to this product.

NCBI GI #

666335637

NCBI GeneID

11163

NCBI Accession #

NP_001287951.1

UniProt Primary Accession #

Q9NZJ9

UniProt Secondary Accession #

Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZK0; Q9NZK1; B7Z916

UniProt Related Accession #

Q9NZJ9

GenBank Nucleotide #

NM_001301022.1

NCBI Official Full Name

diphosphoinositol polyphosphate phosphohydrolase 2 isoform 3

NCBI Official Synonym Full Names

nudix (nucleoside diphosphate linked moiety X)-type motif 4

NCBI Official Symbol

NUDT4

NCBI Official Synonym Symbols

DIPP2; HDCMB47P; DIPP2beta; DIPP2alpha

UniProt Protein Name

Diphosphoinositol polyphosphate phosphohydrolase 2

UniProt Synonym Protein Names

Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2 (EC:3.6.1.-); Nucleoside diphosphate-linked moiety X motif 4; Nudix motif 4

Protein Family

Diphosphoinositol polyphosphate phosphohydrolase

UniProt Gene Name

NUDT4

UniProt Synonym Gene Names

DIPP2; KIAA0487; DIPP-2; Nudix motif 4

UniProt Entry Name

NUDT4_HUMAN

NCBI Protein Information

diphosphoinositol polyphosphate phosphohydrolase 2; DIPP-2; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; diphosphoinositol polyphosphate phosphohydrolase type 2

NCBI Summary for NUDT4

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]

UniProt Comments for NUDT4

NUDT4: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Belongs to the Nudix hydrolase family. DIPP subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.52; Hydrolase

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: intracellular; cytosol

Molecular Function: snoRNA binding; m7G(5')pppN diphosphatase activity; metal ion binding; diphosphoinositol-polyphosphate diphosphatase activity

Biological Process: cyclic-nucleotide-mediated signaling; inositol phosphate metabolic process; cyclic nucleotide metabolic process; intracellular transport; calcium-mediated signaling; regulation of RNA export from nucleus

Research Articles on NUDT4

1. This paper demonstrates that KIAA0487 (AB007956) is the 3'-UTR for human diphosphoinositol polyphosphate phosphohydrolase type II

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NUDT4 recombinant protein

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