Human DOK4 Recombinant Protein – Cat# MBS145601

Docking Protein 4 (DOK4) Human Recombinant Protein

Name: DOK4 Recombinant Protein; Docking Protein 4; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145601
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145601

Description: DOK4 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (1-326 a.a) and having a molecular mass of 39.4kDa.DOK4 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Docking Protein 4 (DOK4), Recombinant Protein

Full Product Name

Recombinant Human Docking Protein 4

Product Gene Name

DOK4 recombinant protein

Product Synonym Names

DOK4 Human; Docking Protein 4 Human Recombinant; docking protein 4; Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMAT NFSD IVKQGYVKMK SRKLGIYRRC WLVFRKSSSK GPQRLEKYPD EKSVCLRGCP KVTEISNVKC VTRLPKETKR QAVAIIFTDD SARTFTCDSE LEAEEWYKTL SVECLGSRLN DISLGEPDLL APGVQCEQTD RFNVFLLPCP NLDVYGECKL QITHENIYLW DIHNPRVKLV SWPLCSLRRY GRDATRFTFE AGRMCDAGEG LYTFQTQEGE QIYQRVHSAT LAIAEQHKRV LLEMEKNVRL LNKGTEHYSY PCTPTTMLPR SAYWHHITGS QNIAEASSYA GEGYGAAQAS SETDLLNRFI LLKPKPSQGD SSEAKTPSQ

Host

E Coli

Form/Format

DOK4 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Molecular Weight

37,028 Da

OMIM

608333

3D Structure

ModBase 3D Structure for Q8TEW6

Product Categories/Family for DOK4 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of DOK4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DOK4 purchase

MBS145601 is a recombinant protein targeting DOK4. Also known as Recombinant Human Docking Protein 4. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DOK4. It may not necessarily be applicable to this product.

NCBI GI #

20070302

NCBI GeneID

55715

NCBI Accession #

NP_060580.2

UniProt Primary Accession #

Q8TEW6

UniProt Secondary Accession #

O75209; Q9BTP2; Q9NVV3

UniProt Related Accession #

Q8TEW6

GenBank Nucleotide #

NM_018110.3

NCBI Official Full Name

docking protein 4

NCBI Official Synonym Full Names

docking protein 4

NCBI Official Symbol

DOK4

UniProt Protein Name

Docking protein 4

UniProt Synonym Protein Names

Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5

Protein Family

Docking protein

UniProt Gene Name

DOK4

UniProt Synonym Gene Names

IRS-5; IRS5

UniProt Entry Name

DOK4_HUMAN

NCBI Protein Information

docking protein 4; IRS-5; IRS5; downstream of tyrosine kinase 4; insulin receptor substrate 5

UniProt Comments for DOK4

DOK4: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in Ret-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of Ret in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Interacts with Ret and TIE2. Interaction with Ret is mediated through the PTB domain and requires phosphorylation of Ret Y1062.

Protein type: Cell development/differentiation; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16q21

Molecular Function: protein binding; receptor signaling protein activity; insulin receptor binding

Biological Process: nervous system development; MAPKKK cascade; transmembrane receptor protein tyrosine kinase signaling pathway

Research Articles on DOK4

1. the current study have explored in more detail the structure and function of the Dok-4 PTB domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DOK4 recombinant protein

Reference Product	PubMed Publications
RET recombinant protein	>5 publications with DOK4 and RET
SRC recombinant protein	>3 publications with DOK4 and SRC
FYN recombinant protein	>2 publications with DOK4 and FYN
GDNF recombinant protein	>2 publications with DOK4 and GDNF
CRK recombinant protein	>1 publications with DOK4 and CRK

Pathways associated with DOK4 recombinant protein

Products by Pathway	Pathway Diagram
Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies	Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram

Diseases associated with DOK4 recombinant protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>3 publications with DOK4 and Adenocarcinoma
Lung Neoplasms Antibodies	>2 publications with DOK4 and Lung Neoplasms
Carcinoma, Squamous Cell Antibodies	>2 publications with DOK4 and Carcinoma, Squamous Cell
Nervous System Diseases Antibodies	>1 publications with DOK4 and Nervous System Diseases
Kidney Diseases Antibodies	>1 publications with DOK4 and Kidney Diseases
Lymphoma Antibodies	>1 publications with DOK4 and Lymphoma
Poisoning Antibodies	>1 publications with DOK4 and Poisoning
Inflammation Antibodies	>1 publications with DOK4 and Inflammation
Breast Neoplasms Antibodies	>1 publications with DOK4 and Breast Neoplasms
Necrosis Antibodies	>1 publications with DOK4 and Necrosis

Organs/Tissues associated with DOK4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>3 publications with DOK4 and Muscle
Lung Antibodies	>3 publications with DOK4 and Lung
Kidney Antibodies	>3 publications with DOK4 and Kidney
Vascular Antibodies	>2 publications with DOK4 and Vascular
Connective Tissue Antibodies	>1 publications with DOK4 and Connective Tissue
Liver Antibodies	>1 publications with DOK4 and Liver
Skin Antibodies	>1 publications with DOK4 and Skin
Embryonic Tissue Antibodies	>1 publications with DOK4 and Embryonic Tissue
Heart Antibodies	>1 publications with DOK4 and Heart
Intestine Antibodies	>1 publications with DOK4 and Intestine