Human TSHB Recombinant Protein – Cat# MBS145678

Thyroid Stimulating Hormone (TSHB) Human Recombinant Protein

Name: TSHB Recombinant Protein; Thyroid Stimulating Hormone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145678
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145678

Description: TSHB Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 141 amino acids (21-138 a.a) and having a molecular mass of 15.9kDa.TSHB is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thyroid Stimulating Hormone (TSHB), Recombinant Protein

Full Product Name

Recombinant Human Thyroid Stimulating Hormone Beta

Product Gene Name

TSHB recombinant protein

Product Synonym Names

TSHB Human; Thyroid Stimulating Hormone Beta Human Recombinant; Thyroid Stimulating Hormone Beta; Thyrotropin Beta Chain; TSH-B; Thyrotropin Subunit Beta; Thyroid-Stimulating Hormone Subunit Beta; TSH-beta; Thyrotropin Alfa; CHNG4

Sequence

MGSSHHH HHH SSGLVPRGSH MGSFCI PTEY TMHIERRECA YCLTINTTIC AGYCMTRDIN GKLFLPKYAL SQDVCTYRDF IYRTVEIPGC PLHVAPYFSY PVALSCKCGK CNTDYSDCIH EAIKTNYCTK PQKSYLVGFS V

Host

E Coli

Form/Format

TSHB protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.

Molecular Weight

10,624 Da

OMIM

188540

3D Structure

ModBase 3D Structure for P01222

Product Categories/Family for TSHB recombinant protein

Hormones; Hormones; TSH

Other Notes

Small volumes of TSHB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSHB purchase

MBS145678 is a recombinant protein targeting TSHB. Also known as Recombinant Human Thyroid Stimulating Hormone Beta. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TSHB. It may not necessarily be applicable to this product.

NCBI GI #

115430099

NCBI GeneID

7252

NCBI Accession #

NP_000540.2

UniProt Primary Accession #

P01222

UniProt Secondary Accession #

Q16163; B1AKP0

UniProt Related Accession #

P01222

GenBank Nucleotide #

NM_000549.4

NCBI Official Full Name

thyrotropin subunit beta isoform 1

NCBI Official Synonym Full Names

thyroid stimulating hormone, beta

NCBI Official Symbol

TSHB

NCBI Official Synonym Symbols

TSH-B; TSH-BETA

UniProt Protein Name

Thyrotropin subunit beta

UniProt Synonym Protein Names

Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; INN: Thyrotropin alfa

Protein Family

Thyrotropin

UniProt Gene Name

TSHB

UniProt Synonym Gene Names

TSH-B; TSH-beta

UniProt Entry Name

TSHB_HUMAN

NCBI Protein Information

thyrotropin subunit beta; thyrotropin beta chain

NCBI Summary for TSHB

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

UniProt Comments for TSHB

TSHB: Indispensable for the control of thyroid structure and metabolism. Belongs to the glycoprotein hormones subunit beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: extracellular region

Molecular Function: hormone activity

Biological Process: G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; cellular protein metabolic process; cell-cell signaling; response to estrogen stimulus; peptide hormone processing; response to calcium ion; response to vitamin A

Disease: Hypothyroidism, Congenital, Nongoitrous, 4

Research Articles on TSHB

1. bTSH Induces IL-6 Protein and mRNA in Orbital Fibroblasts and Fibrocytes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TSHB recombinant protein

Reference Product	PubMed Publications
TRH recombinant protein	>7 publications with TSHB and TRH
TSHR recombinant protein	>7 publications with TSHB and TSHR
POU1F1 recombinant protein	>6 publications with TSHB and POU1F1
PRL recombinant protein	>5 publications with TSHB and PRL
TRHR recombinant protein	>5 publications with TSHB and TRHR
CGA recombinant protein	>5 publications with TSHB and CGA
LHX2 recombinant protein	>1 publications with TSHB and LHX2

Pathways associated with TSHB recombinant protein

Products by Pathway	Pathway Diagram
Amine-derived Hormones Pathway antibodies	Amine-derived Hormones Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Glycoprotein Hormones Pathway antibodies	Glycoprotein Hormones Pathway Diagram

Diseases associated with TSHB recombinant protein

Disease Name	Pubmed Publications
Thyroid Diseases Antibodies	>13 publications with TSHB and Thyroid Diseases
Hypothyroidism Antibodies	>11 publications with TSHB and Hypothyroidism
Nervous System Diseases Antibodies	>3 publications with TSHB and Nervous System Diseases
Brain Diseases Antibodies	>2 publications with TSHB and Brain Diseases
Liver Diseases Antibodies	>2 publications with TSHB and Liver Diseases
Hyperthyroidism Antibodies	>2 publications with TSHB and Hyperthyroidism
Carcinoma, Hepatocellular Antibodies	>2 publications with TSHB and Carcinoma, Hepatocellular
Inflammation Antibodies	>1 publications with TSHB and Inflammation
Infertility, Male Antibodies	>1 publications with TSHB and Infertility, Male
Kidney Diseases Antibodies	>1 publications with TSHB and Kidney Diseases

Organs/Tissues associated with TSHB recombinant protein

Organ/Tissue Name	Pubmed Publications
Pituitary Gland Antibodies	>12 publications with TSHB and Pituitary Gland
Pancreas Antibodies	>1 publications with TSHB and Pancreas