Guanine Nucleotide Binding Protein Beta Polypeptide 1 (GNB1) Human Recombinant Protein

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

G-beta 1: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family.

Protein type: G protein; G protein, heterotrimeric beta; G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: photoreceptor inner segment; membrane; lysosomal membrane; dendrite; plasma membrane; heterotrimeric G-protein complex; intracellular; vesicle

Molecular Function: GTPase activity; GTPase binding; protein binding; signal transducer activity; spectrin binding; protein complex binding; type 1 angiotensin receptor binding

Biological Process: phototransduction, visible light; platelet activation; acetylcholine receptor signaling, muscarinic pathway; sensory perception of taste; signal transduction; rhodopsin mediated signaling; synaptic transmission; cell proliferation; elevation of cytosolic calcium ion concentration; regulation of rhodopsin mediated signaling; retina development in camera-type eye; Ras protein signal transduction; energy reserve metabolic process; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); blood coagulation; dopamine receptor, adenylate cyclase activating pathway