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Coxsackie Virus and Adenovirus Receptor (CXADR) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145737

Description: CXADR Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 241 amino acids (20-237) and having a molecular mass of 26.0kDa.CXADR is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Coxsackie Virus And Adenovirus Receptor (CXADR), Recombinant Protein
Full Product Name
Recombinant Human Coxsackie Virus And Adenovirus Receptor
Product Gene Name
CXADR recombinant protein
Product Synonym Names
CXADR Human; Coxsackie Virus And Adenovirus Receptor Human Recombinant; Coxsackie Virus And Adenovirus Receptor; CAR; 46 KD Coxsackievirus And Adenovirus Receptor (CAR) Protein 11; Coxsackievirus B-Adenovirus Receptor; HCVADR; CVB3-Binding Protein; CAR4/6; HCAR
Sequence
MGSSHHH HHH SSGLVPRGSH MGSLSI TTPE EMIEKAKGET AYLPCKFTLS PEDQGPLDIE WLISPADNQK VDQVIILYSG DKIYDDYYPD LKGRVHFTSN DLKSGDASIN VTNLQLSDIG TYQCKVKKAP GVANKKIHLV VLVKPSGARC YVDGSEEIGS DFKIKCEPKE GSLPLQYEWQ KLSDSQKMPT SWLAEMTSSV ISVKNASSEY SGTYSCTVRN RVGSDQCLLR LNVVPPSNKA G.
Host
E Coli
Form/Format
The CXADR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Molecular Weight
35,570 Da
OMIM
602621
3D Structure
ModBase 3D Structure for P78310

Product Categories/Family for CXADR recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of CXADR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXADR purchase

MBS145737 is a recombinant protein targeting CXADR. Also known as Recombinant Human Coxsackie Virus And Adenovirus Receptor. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXADR. It may not necessarily be applicable to this product.

NCBI GI #
333470703
NCBI GeneID
1525
NCBI Accession #
NP_001193992.1
UniProt Primary Accession #
P78310
UniProt Secondary Accession #
O00694; Q8WWT6; Q8WWT7; Q8WWT8; Q9UKV4; B2R8V8; B7WPI3; D3YHP0
UniProt Related Accession #
P78310
GenBank Nucleotide #
NM_001207063.1
NCBI Official Full Name
coxsackievirus and adenovirus receptor isoform 2
NCBI Official Synonym Full Names
coxsackie virus and adenovirus receptor
NCBI Official Symbol
CXADR
NCBI Official Synonym Symbols
CAR; HCAR; CAR4/6
UniProt Protein Name
Coxsackievirus and adenovirus receptor
UniProt Synonym Protein Names
CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR
Protein Family
Coxsackievirus and adenovirus receptor
UniProt Gene Name
CXADR
UniProt Synonym Gene Names
CAR; CAR; hCAR
UniProt Entry Name
CXAR_HUMAN
NCBI Protein Information
coxsackievirus and adenovirus receptor; 46 kD coxsackievirus and adenovirus receptor (CAR) protein; CVB3-binding protein; HCVADR; coxsackievirus B-adenovirus receptor

NCBI Summary for CXADR

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
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UniProt Comments for CXADR

CXADR: a component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1 located in the plasma membrane of PMN.

Protein type: Receptor, misc.; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: extracellular space; neuron projection; protein complex; tight junction; integral to plasma membrane; apicolateral plasma membrane; basolateral plasma membrane; acrosome; extracellular region; intercellular junction; lipid raft; nucleoplasm; adherens junction; growth cone; plasma membrane; neuromuscular junction; cell junction; filopodium

Molecular Function: integrin binding; viral receptor activity; identical protein binding; protein binding; beta-catenin binding; cell adhesion molecule binding; PDZ domain binding; receptor binding

Biological Process: mitochondrion organization and biogenesis; intercellular junction assembly and maintenance; neutrophil chemotaxis; regulation of immune response; entry of virus into host cell; heart development; gamma-delta T cell activation; heterophilic cell adhesion; cardiac muscle fiber development; homotypic cell-cell adhesion; actin cytoskeleton reorganization; germ cell migration; blood coagulation; leukocyte migration; defense response to virus
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Research Articles on CXADR

1. This study shows for the first time that lovastatin reduces the expression of CAR and subsequently the replication of CVB3 in human umbilical vein endothelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXADR recombinant protein

 Reference Product  PubMed Publications
 LNX1 recombinant protein  >1 publications with CXADR and LNX1

Pathways associated with CXADR recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Viral Myocarditis Pathway antibodies  Viral Myocarditis Pathway Diagram

Diseases associated with CXADR recombinant protein

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >4 publications with CXADR and Heart Diseases
 Cardiovascular Diseases Antibodies  >4 publications with CXADR and Cardiovascular Diseases
 Edema Antibodies  >1 publications with CXADR and Edema
 Heart Failure Antibodies  >1 publications with CXADR and Heart Failure
 Hypertension Antibodies  >1 publications with CXADR and Hypertension
 Inflammation Antibodies  >1 publications with CXADR and Inflammation

Organs/Tissues associated with CXADR recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >6 publications with CXADR and Heart
 Lung Antibodies  >3 publications with CXADR and Lung
 Testis Antibodies  >3 publications with CXADR and Testis
 Brain Antibodies  >3 publications with CXADR and Brain
 Embryonic Tissue Antibodies  >2 publications with CXADR and Embryonic Tissue
 Vascular Antibodies  >2 publications with CXADR and Vascular
 Kidney Antibodies  >1 publications with CXADR and Kidney
 Stomach Antibodies  >1 publications with CXADR and Stomach
 Eye Antibodies  >1 publications with CXADR and Eye
 Muscle Antibodies  >1 publications with CXADR and Muscle
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