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Tankyrase-1 (TNKS) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1458481

MBS1458481 is a recombinant protein targeting Tnks. Also known as Recombinant Mouse Tankyrase-1 (Tnks) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$860 / 0.05 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tankyrase-1 (Tnks), Recombinant Protein
Full Product Name
Recombinant Mouse Tankyrase-1 (Tnks) , partial
Product Gene Name
Tnks recombinant protein
Product Synonym Gene Name
Tnks
Sequence
APEDKEYQSV EEEMQSTIRE HRDGGNAGGI FNRYNVIRIQ KVVNKKLRER FCHRQKEVSE ENHNHHNERM LFHGSPFINA IIHKGFDERH AYIGGMFGAG IYFAENSSKS NQYVYGIGGG TGCPTHKDRS CYICHRQMLF CRVTLGKSFL QFSTMKMAHA PPGHHSVIGR PSVNGLAYAE YVIYRGEQAY PEYLITYQIM KPEAPS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
106,651 Da
Sequence Positions
1105-1310. partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q6PFX9
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tnks recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tnks. It may not necessarily be applicable to this product.

NCBI GI #
87239974
NCBI GeneID
21951
NCBI Accession #
NP_780300.2
UniProt Primary Accession #
Q6PFX9
UniProt Secondary Accession #
Q8BX62
UniProt Related Accession #
Q6PFX9
GenBank Nucleotide #
NM_175091.3
NCBI Official Full Name
tankyrase-1
NCBI Official Synonym Full Names
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
NCBI Official Symbol
Tnks
NCBI Official Synonym Symbols
ARTD5; TANK1; C86528; mTNKS1; AI662855; 4930554K12Rik; D130072O21Rik
UniProt Protein Name
Tankyrase-1
UniProt Synonym Protein Names
ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; TRF1-interacting ankyrin-related ADP-ribose polymerase 1; Tankyrase I
Protein Family
Tankyrase
UniProt Gene Name
Tnks
UniProt Synonym Gene Names
Tnks1; TANK1; ARTD5; Tankyrase I
NCBI Protein Information
tankyrase-1

UniProt Comments for Tnks

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity ().
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Research Articles on Tnks

1. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Tnks recombinant protein

 Reference Product  PubMed Publications
 Terf1 recombinant protein  >4 publications with Tnks and Terf1
 Axin1 recombinant protein  >2 publications with Tnks and Axin1
 Kif3a recombinant protein  >1 publications with Tnks and Kif3a

Pathways associated with Tnks recombinant protein

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Degradation Of AXIN Pathway antibodies  Degradation Of AXIN Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram

Diseases associated with Tnks recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >41 publications with Tnks and Neoplasms
 Breast Neoplasms Antibodies  >7 publications with Tnks and Breast Neoplasms
 Carcinoma Antibodies  >6 publications with Tnks and Carcinoma
 Colorectal Neoplasms Antibodies  >6 publications with Tnks and Colorectal Neoplasms
 Central Nervous System Neoplasms Antibodies  >5 publications with Tnks and Central Nervous System Neoplasms
 Ovarian Neoplasms Antibodies  >3 publications with Tnks and Ovarian Neoplasms
 Necrosis Antibodies  >3 publications with Tnks and Necrosis
 Lymphoma Antibodies  >2 publications with Tnks and Lymphoma
 Ovarian Diseases Antibodies  >2 publications with Tnks and Ovarian Diseases
 Fatty Liver Antibodies  >1 publications with Tnks and Fatty Liver

Organs/Tissues associated with Tnks recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with Tnks and Blood
 Muscle Antibodies  >7 publications with Tnks and Muscle
 Brain Antibodies  >7 publications with Tnks and Brain
 Stomach Antibodies  >5 publications with Tnks and Stomach
 Kidney Antibodies  >4 publications with Tnks and Kidney
 Bone Marrow Antibodies  >4 publications with Tnks and Bone Marrow
 Bone Antibodies  >4 publications with Tnks and Bone
 Lung Antibodies  >4 publications with Tnks and Lung
 Liver Antibodies  >2 publications with Tnks and Liver
 Heart Antibodies  >2 publications with Tnks and Heart
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