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Neuralized Homolog 2 (NEURL2) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145920

Description: NEURL2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285) and having a molecular mass of 34.1 kDa.NEURL2 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Product Overview

Online Datasheet in PDF
Product Name
Neuralized Homolog 2 (NEURL2), Recombinant Protein
Full Product Name
Recombinant Human Neuralized Homolog 2
Product Gene Name
NEURL2 recombinant protein
Product Synonym Names
NEURL2 Human; Neuralized Homolog 2 Human Recombinant; 800x600 800x600 800x600 neuralized homolog 2; C20orf163; OZZ; Ozz-E3; Neuralized-like protein 2; Neuralized Homolog 2; NEURL2. 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Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAA ASEP VDSGALWGLE RPEPPPTRFH RVHGANIRVD PSGTRATRVE SFAHGVCFSR EPLAPGQVFL VEIEEKELGW CGHLRLGLTA LDPASLAPVP EFSLPDLVNL GHTWVFAITR HHNRVPREGR PEAEAAAPSR PPTLLVEPYL RIEQFRIPRD RLVGRSRPGL YSHLLDQLYE LNVLPPTARR SRLGVLFCPR PDGTADMHII INGEDMGPSA RGLPAAQPLY AVVDVFASTK SVRLVQLEYG LPSLQTLCRL VIQRSMVHRL AIDGLHLPKE LKDFCKYE
Host
E Coli
Form/Format
The NEURL2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
31,690 Da
OMIM
608597
3D Structure
ModBase 3D Structure for Q9BR09

Product Categories/Family for NEURL2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of NEURL2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NEURL2 purchase

MBS145920 is a recombinant protein targeting NEURL2. Also known as Recombinant Human Neuralized Homolog 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NEURL2. It may not necessarily be applicable to this product.

NCBI GI #
512749772
NCBI GeneID
140825
NCBI Accession #
NP_001265464.1
UniProt Primary Accession #
Q9BR09
UniProt Secondary Accession #
Q3KR34
UniProt Related Accession #
Q9BR09
GenBank Nucleotide #
NM_001278535.1
NCBI Official Full Name
neuralized-like protein 2 isoform 2
NCBI Official Synonym Full Names
neuralized E3 ubiquitin protein ligase 2
NCBI Official Symbol
NEURL2
NCBI Official Synonym Symbols
OZZ; OZZ-E3; C20orf163
UniProt Protein Name
Neuralized-like protein 2
Protein Family
Neuralized-like protein
UniProt Gene Name
NEURL2
UniProt Synonym Gene Names
C20orf163
UniProt Entry Name
NEUL2_HUMAN
NCBI Protein Information
neuralized-like protein 2; neuralized homolog 2

NCBI Summary for NEURL2

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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UniProt Comments for NEURL2

NEURL2: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: muscle tendon junction; VCB complex

Biological Process: protein ubiquitination; sarcomere organization
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Research Articles on NEURL2

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NEURL2 recombinant protein

 Reference Product  PubMed Publications
 CTNNB1 recombinant protein  >1 publications with NEURL2 and CTNNB1

Diseases associated with NEURL2 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with NEURL2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >1 publications with NEURL2 and Disease Models, Animal

Organs/Tissues associated with NEURL2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with NEURL2 and Muscle
 Heart Antibodies  >1 publications with NEURL2 and Heart
 Brain Antibodies  >1 publications with NEURL2 and Brain
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