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15 Kda Selenoprotein (SEP15) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145940

Description: SEP15 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids (29-165 a.a) and having a molecular mass of 17.7kDa.SEP15 is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Product Overview

Online Datasheet in PDF
Product Name
15 KDa Selenoprotein (SEP15), Recombinant Protein
Full Product Name
Recombinant Human 15 KDa Selenoprotein
Product Gene Name
Product Synonym Names
SEP15 Human; 15 KDa Selenoprotein Human Recombinant; 15 KDa Selenoprotein; SEP15
Sequence
MGSSHHH HHH SSGLVPRGSH MGSVSA FGAE FSSEACRELG FSSNLLCSSC DLLGQFNLLQ LDPDCRGCCQ EEAQFETKKL YAGAILEVCG CKLGRFPQVQ AFVRSDKPKL FRGLQIKYVR GSDPVLKLLD DNGNIAEELS ILKWNTDSVE EFLSEKLERI
Host
E Coli
Form/Format
SEP15 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Sterile Filtered clear solution.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Molecular Weight
13,219 Da
OMIM
606254
3D Structure
ModBase 3D Structure for O60613

Other Notes

Small volumes of SEP15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEP15 purchase

MBS145940 is a recombinant protein targeting SEP15. Also known as Recombinant Human 15 KDa Selenoprotein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SEP15. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
15 kDa selenoprotein isoform 1
NCBI Official Symbol
SEP15
UniProt Protein Name
15 kDa selenoprotein
Protein Family
UniProt Gene Name
SEP15
UniProt Entry Name
SEP15_HUMAN
NCBI Protein Information
15 kDa selenoprotein

NCBI Summary for SEP15

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies in mouse suggest that this selenoprotein may have redox function and may be involved in the quality control of protein folding. This gene is localized on chromosome 1p31, a genetic locus commonly mutated or deleted in human cancers. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for SEP15

SEP15: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum. Belongs to the selenoprotein M/SEP15 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: endoplasmic reticulum lumen

Molecular Function: selenium binding

Biological Process: 'de novo' posttranslational protein folding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SEP15 recombinant protein

 Products by Pathway  Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
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