Purine-Rich Element Binding Protein B (PURB) Human Recombinant Protein

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

Pur-beta: Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs. Belongs to the PUR DNA-binding protein family.

Protein type: DNA-binding; RNA-binding

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: nucleoplasm; DNA replication factor A complex; nucleus

Molecular Function: mRNA binding; double-stranded DNA binding; SMAD binding; transcription factor binding; transcription factor activity; single-stranded DNA binding

Biological Process: regulation of myeloid cell differentiation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter