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Frizzled-Related (FRZB) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145979

Description: FRZB Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 316 amino acids (33-325 a.a) and having a molecular mass of 35kDa.FRZB is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Frizzled-Related (FRZB), Recombinant Protein
Full Product Name
Recombinant Human Frizzled-Related Protein
Product Gene Name
FRZB recombinant protein
Product Synonym Names
FRZB Human; Frizzled-Related Protein Human Recombinant; Secreted frizzled-related protein 3; sFRP-3; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1; FRZB; FIZ; FRE; FRP; FRZB1; SFRP3; OS1; FZRB; hFIZ; FRP-3; SFRP3; SRFP3; FRZB-PEN
Sequence
MGSSHHH HHH SSGLVPRGSH MGSAAC EPVR IPLCKSLPWN MTKMPNHLHH STQANAILAI EQFEGLLGTH CSPDLLFFLC AMYAPICTID FQHEPIKPCK SVCERARQGC EPILIKYRHS WPENLACEEL PVYDRGVCIS PEAIVTADGA DFPMDSSNGN CRGASSERCK CKPIRATQKT YFRNNYNYVI RAKVKEIKTK CHDVTAVVEV KEILKSSLVN IPRDTVNLYT SSGCLCPPLN VNEEYIIMGY EDEERSRLLL VEGSIAEKWK DRLGKKVKRW DMKLRHLGLS KSDSSNSDST QSQKSGRNSN PRQARN.
Host
E Coli
Form/Format
FRZB protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
36,254 Da
OMIM
165720
3D Structure
ModBase 3D Structure for Q92765

Product Categories/Family for FRZB recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of FRZB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FRZB purchase

MBS145979 is a recombinant protein targeting FRZB. Also known as Recombinant Human Frizzled-Related Protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FRZB. It may not necessarily be applicable to this product.

NCBI GI #
38455388
NCBI GeneID
2487
NCBI Accession #
NP_001454.2
UniProt Primary Accession #
Q92765
UniProt Secondary Accession #
O00181; Q99686
UniProt Related Accession #
Q92765
GenBank Nucleotide #
NM_001463.3
NCBI Official Full Name
secreted frizzled-related protein 3
NCBI Official Synonym Full Names
frizzled-related protein
NCBI Official Symbol
FRZB
NCBI Official Synonym Symbols
FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN
UniProt Protein Name
Secreted frizzled-related protein 3
UniProt Synonym Protein Names
Frezzled; Fritz; Frizzled-related protein 1; FrzB-1
Protein Family
Frizzy aggregation protein
UniProt Gene Name
FRZB
UniProt Synonym Gene Names
FIZ; FRE; FRP; FRZB1; SFRP3; sFRP-3
UniProt Entry Name
SFRP3_HUMAN
NCBI Protein Information
secreted frizzled-related protein 3; frezzled; frizzled homolog-related; frizzled-related protein 1; sFRP-3

NCBI Summary for FRZB

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

UniProt Comments for FRZB

FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: extracellular space; membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity

Biological Process: negative regulation of cell proliferation; convergent extension involved in organogenesis; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; positive regulation of fat cell differentiation; negative regulation of cell growth; neural crest cell differentiation; skeletal development

Disease: Osteoarthritis Susceptibility 1
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Research Articles on FRZB

1. Our results suggest that the sFRP3 c.970C>G and sFRP4 c.958C>A polymorphisms may be genetic factors associated with the prevalence of osteoporosis at the femoral neck in postmenopausal Korean women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FRZB recombinant protein

 Reference Product  PubMed Publications
 WNT3A recombinant protein  >22 publications with FRZB and WNT3A
 ASPN recombinant protein  >7 publications with FRZB and ASPN
 SMOC2 recombinant protein  >2 publications with FRZB and SMOC2
 MATN3 recombinant protein  >2 publications with FRZB and MATN3
 TNFAIP6 recombinant protein  >1 publications with FRZB and TNFAIP6
 MYOD1 recombinant protein  >1 publications with FRZB and MYOD1

Pathways associated with FRZB recombinant protein

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram

Diseases associated with FRZB recombinant protein

 Disease Name  Pubmed Publications
 Osteoarthritis Antibodies  >49 publications with FRZB and Osteoarthritis
 Disease Models, Animal Antibodies  >14 publications with FRZB and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >11 publications with FRZB and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >10 publications with FRZB and Adenocarcinoma
 Kidney Diseases Antibodies  >8 publications with FRZB and Kidney Diseases
 Breast Neoplasms Antibodies  >7 publications with FRZB and Breast Neoplasms
 Kidney Neoplasms Antibodies  >7 publications with FRZB and Kidney Neoplasms
 Lung Neoplasms Antibodies  >7 publications with FRZB and Lung Neoplasms
 Inflammation Antibodies  >5 publications with FRZB and Inflammation
 Liver Neoplasms Antibodies  >4 publications with FRZB and Liver Neoplasms

Organs/Tissues associated with FRZB recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >85 publications with FRZB and Bone
 Embryonic Tissue Antibodies  >42 publications with FRZB and Embryonic Tissue
 Muscle Antibodies  >25 publications with FRZB and Muscle
 Connective Tissue Antibodies  >19 publications with FRZB and Connective Tissue
 Eye Antibodies  >16 publications with FRZB and Eye
 Liver Antibodies  >14 publications with FRZB and Liver
 Kidney Antibodies  >14 publications with FRZB and Kidney
 Brain Antibodies  >14 publications with FRZB and Brain
 Bone Marrow Antibodies  >10 publications with FRZB and Bone Marrow
 Lung Antibodies  >10 publications with FRZB and Lung
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