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Receptor-Associated Protein of the Synapse (RAPSN) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145997

Description: RAPSN Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 435 amino acids (1-412aa) and having a molecular mass of 48.8kDa.RAPSN is fused to a 23 amino acid His-tag at N-terminus & purified by… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Receptor-Associated Protein Of The Synapse (RAPSN), Recombinant Protein
Full Product Name
Recombinant Mouse Receptor-Associated Protein Of The Synapse
Product Gene Name
RAPSN recombinant protein
Product Synonym Names
RAPSN Mouse; Receptor-Associated Protein Of The Synapse Mouse Recombinant; Receptor-Associated Protein Of The Synapse; 43 KDa Postsynaptic Protein; Acetylcholine Receptor-Associated 43 KDa Protein; RNF205; RING Finger Protein 205; rapsyn; Receptor-Associated Protein Of The Synapse; 43Kd; 43 KDa Receptor-Associated Protein Of The Synapse; RAPSYN; RAPsyn; CMS1D; CMS1E
Sequence
MGSSHHH HHH SSGLVPRGSH MGSMGQ DQTK QQIEKGLQLY QSNQTEKALQ VWMKVLEKGS DLVGRFRVLG CLVTAHSEMG RYKEMLKFAV VQIDTARGLE DADFLLESYL NLARSNEKLC EFHKTISYCK TCLGLPGTRA GAQLGGQVSL SMGNAFLGLS LFQKALESFE KALRYAHNND DTMLECRVCC SLGSFYAQVK DYEKALFFPC KAAELVNDYG KGWSLKYRAM SQYHMAVAYR LLGHLGSAME CCEESMKIAL QHGDRPLQAL CLLCFADIHR SRGDLETAFP RYDSAMSIMT EIGNRLGQVH VLLGVAKCWM ARKVQDKALD AIEKAQDLAE EVGNKLSQLK LHCLSESIYR SKGLQRELRT HVVRFHECVE ETELYCGLCG ESIGERNSRL QALPCSHIFH LRCLQNNGTR SCPNCRRSSM KPGFV
Host
E Coli
Form/Format
RAPSN protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 85% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Molecular Weight
46,393 Da
3D Structure
ModBase 3D Structure for P12672

Product Categories/Family for RAPSN recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of RAPSN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAPSN purchase

MBS145997 is a recombinant protein targeting RAPSN. Also known as Recombinant Mouse Receptor-Associated Protein Of The Synapse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RAPSN. It may not necessarily be applicable to this product.

NCBI GI #
224967081
NCBI GeneID
19400
NCBI Accession #
NP_033049.2
UniProt Primary Accession #
P12672
UniProt Secondary Accession #
Q2M2N6
UniProt Related Accession #
P12672
GenBank Nucleotide #
NM_009023.3
NCBI Official Full Name
43 kDa receptor-associated protein of the synapse
NCBI Official Synonym Full Names
receptor-associated protein of the synapse
NCBI Official Symbol
Rapsn
NCBI Official Synonym Symbols
Raps; 43kDa; Nraps; rapsyn
UniProt Protein Name
43 kDa receptor-associated protein of the synapse
UniProt Synonym Protein Names
43 kDa postsynaptic protein; Acetylcholine receptor-associated 43 kDa protein
Protein Family
43 kDa receptor-associated protein of the synapse
UniProt Gene Name
Rapsn
UniProt Synonym Gene Names
RAPsyn
UniProt Entry Name
RAPSN_MOUSE
NCBI Protein Information
43 kDa receptor-associated protein of the synapse; 43 kDa postsynaptic protein; 43kDa acetylcholine receptor-associated protein; acetylcholine receptor-associated 43 kDa protein; receptor-associated protein of the synapse, 43 kDa

UniProt Comments for RAPSN

RAPSN: Thought to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Defects in RAPSN are a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD). A postsynaptic congenital myasthenic syndrome. Congenital myasthenic syndromes (CMS) are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic, synaptic, or postsynaptic proteins. Defects in RAPSN are the cause of fetal akinesia deformation sequence (FADS); also known as Pena- Shokeir syndrome type 1 or fetal akinesia sequence or arthrogryposis multiplex congenita with pulmonary hypoplasia. FADS is a rare condition characterized by decreased intrauterine fetal movement, congenital limb contractures, pulmonary hypoplasia, polyhydramnios and craniofacial abnormalities. Belongs to the RAPsyn family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Ubiquitin conjugating system

Cellular Component: Golgi apparatus; postsynaptic membrane; centrosome; cytoskeleton; membrane; cytoplasm; plasma membrane; synapse; neuromuscular junction; cell junction

Molecular Function: ionotropic glutamate receptor binding; zinc ion binding; protein anchor; metal ion binding; acetylcholine receptor binding

Biological Process: synaptic transmission; positive regulation of neuron apoptosis; synaptic transmission, cholinergic
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Research Articles on RAPSN

1. Molecular modelling, immunoprecipitation and bimolecular fluorescence complementation approaches identify an alpha-helical stretch of rapsyn to be crucial for binding to the dimerisation and docking domain of PKA type I.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RAPSN recombinant protein

 Reference Product  PubMed Publications
 Chrna1 recombinant protein  >10 publications with RAPSN and Chrna1
 Musk recombinant protein  >6 publications with RAPSN and Musk

Diseases associated with RAPSN recombinant protein

 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >4 publications with RAPSN and Muscular Diseases
 Autoimmune Diseases Antibodies  >3 publications with RAPSN and Autoimmune Diseases
 Edema Antibodies  >2 publications with RAPSN and Edema
 MYASTHENIC SYNDROME, CONGENITAL, ASSOCIATED WITH ACETYLCHOLINE RECEPTOR DEFICIENCY Antibodies  >2 publications with RAPSN and MYASTHENIC SYNDROME, CONGENITAL, ASSOCIATED WITH ACETYLCHOLINE RECEPTOR DEFICIENCY
 Cognition Disorders Antibodies  >1 publications with RAPSN and Cognition Disorders
 Pena Shokeir syndrome, type 1 Antibodies  >1 publications with RAPSN and Pena Shokeir syndrome, type 1

Organs/Tissues associated with RAPSN recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >28 publications with RAPSN and Muscle
 Brain Antibodies  >2 publications with RAPSN and Brain
 Skin Antibodies  >1 publications with RAPSN and Skin
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