KIN Human Recombinant Protein

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

KIN: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro. Belongs to the KIN17 family.

Protein type: DNA replication; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: nuclear matrix; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: DNA binding; RNA binding; metal ion binding; double-stranded DNA binding

Biological Process: viral reproduction; DNA repair; mRNA processing; DNA replication; response to DNA damage stimulus; DNA recombination