Human GTF2A1 Recombinant Protein – Cat# MBS146083

General Transcription Factor IIA, 1 (GTF2A1) Human Recombinant Protein

Name: GTF2A1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146083
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146083

Description: GTF2A1 Human Recombinant produced in E Coli is. a single polypeptide chain containing 297 amino acids (1-274) and having a molecular mass of 32.2kDa. GTF2A1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

General Transcription Factor IIA, 1 (GTF2A1), Recombinant Protein

Full Product Name

Recombinant Human General Transcription Factor IIA, 1

Product Gene Name

GTF2A1 recombinant protein

Product Synonym Names

GTF2A1 Human; General Transcription Factor IIA, 1 Human Recombinant; General transcription factor IIA; 1; 19/37kDa; TF2A1; TFIIA; TFIIA-42; TFIIAL; Transcription initiation factor IIA subunit 1; Transcription initiation factor TFIIA 42 kDa subunit; GTF2A1

Sequence

MGSSHHH HHH SSGLVPRGSH MGSMAN SANT NTVPKLYRSV IEDVINDVRD IFLDDGVDEQ VLMELKTLWE NKLMQSRAVD GFHSEEQQLL LQVQQQHQPQ QQQHHHHHHH QQAQPQQTVP QQAQTQQVLI PASQQATAPQ VIVPDSKLIQ HMNASNMSAA ATAATLALPA GVTPVQQILT NSGQLLQVVR AANGAQYIFQ PQQSVVLQQQ VIPQMQPGGV QAPVIQQVLA PLPGGISPQT GVIIQPQQIL FTGNKTQVIP TTVAAPTPAQ AQITATGQQQ PQAQPAQTQA PLVLQVD

Host

E Coli

Form/Format

The GTF2A1 solution (0.5mg/ml) contains 20mM Tris-HCl(pH8.0), 20% glycerol, 0.15M NaCl and 1mM DTT.
Sterile Filtered clear solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Molecular Weight

37,152 Da

OMIM

600520

3D Structure

ModBase 3D Structure for P52655

Product Categories/Family for GTF2A1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; General Transcription Factor

Other Notes

Small volumes of GTF2A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GTF2A1 purchase

MBS146083 is a recombinant protein targeting GTF2A1. Also known as Recombinant Human General Transcription Factor IIA, 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GTF2A1. It may not necessarily be applicable to this product.

NCBI GI #

525313614

NCBI GeneID

2957

NCBI Accession #

NP_001265869.1

UniProt Primary Accession #

P52655

UniProt Secondary Accession #

Q3KNQ9

UniProt Related Accession #

P52655

GenBank Nucleotide #

NM_001278940.1

NCBI Official Full Name

transcription initiation factor IIA subunit 1 isoform 3

NCBI Official Synonym Full Names

general transcription factor IIA, 1, 19/37kDa

NCBI Official Symbol

GTF2A1

NCBI Official Synonym Symbols

TF2A1; TFIIA; TFIIAL; TFIIA-42

UniProt Protein Name

Transcription initiation factor IIA subunit 1

UniProt Synonym Protein Names

General transcription factor IIA subunit 1; TFIIAL; Transcription initiation factor TFIIA 42 kDa subunit; TFIIA-42

Protein Family

Transcription initiation factor

UniProt Gene Name

GTF2A1

UniProt Synonym Gene Names

TF2A1; TFIIA-42

UniProt Entry Name

TF2AA_HUMAN

NCBI Protein Information

transcription initiation factor IIA subunit 1; TFIIA alpha, p55, isoform 1; general transcription factor IIA subunit 1; glucose regulated protein, 58kD pseudogene; transcription initiation factor TFIIA 42 kDa subunit

NCBI Summary for GTF2A1

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]

UniProt Comments for GTF2A1

GTF2A1: a general transcription factor that plays an important role in transcriptional activation. A component of the transcription machinery of RNA polymerase II. Phosphorylated by Taf(II) 250 on serines that regulate TBP binding. Interacts with TBP (the TATA-binding protein). Two isoforms, 42 kDa and 37 kDa, are produced by alternative initiation.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 14q31.1

Cellular Component: nucleoplasm; cytoplasm; transcription factor TFIIA complex

Molecular Function: protein binding; DNA binding; TATA-binding protein binding; protein heterodimerization activity; transcription coactivator activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; gene expression

Research Articles on GTF2A1

1. GTF2A1 alone, or GTF2A1 plus HAAO are excellent candidate biomarkers for detecting Ovarian cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GTF2A1 recombinant protein

Reference Product	PubMed Publications
GTF2A2 recombinant protein	>1 publications with GTF2A1 and GTF2A2
TBP recombinant protein	>1 publications with GTF2A1 and TBP

Pathways associated with GTF2A1 recombinant protein

Products by Pathway	Pathway Diagram
Basal Transcription Factors Pathway antibodies	Basal Transcription Factors Pathway Diagram
Basal Transcription Factors Pathway antibodies	Basal Transcription Factors Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
HIV Infection Pathway antibodies	HIV Infection Pathway Diagram
HIV Life Cycle Pathway antibodies	HIV Life Cycle Pathway Diagram
HIV Transcription Initiation Pathway antibodies	HIV Transcription Initiation Pathway Diagram
Late Phase Of HIV Life Cycle Pathway antibodies	Late Phase Of HIV Life Cycle Pathway Diagram
RNA Polymerase II HIV Promoter Escape Pathway antibodies	RNA Polymerase II HIV Promoter Escape Pathway Diagram
RNA Polymerase II Pre-transcription Events Pathway antibodies	RNA Polymerase II Pre-transcription Events Pathway Diagram

Diseases associated with GTF2A1 recombinant protein

Disease Name	Pubmed Publications
Ovarian Neoplasms Antibodies	>1 publications with GTF2A1 and Ovarian Neoplasms

Organs/Tissues associated with GTF2A1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Stomach Antibodies	>1 publications with GTF2A1 and Stomach
Testis Antibodies	>1 publications with GTF2A1 and Testis