Arsa Arsenite Transporter (ASNA1) Human Recombinant Protein

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

ASNA1: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. Belongs to the arsA ATPase family.

Protein type: EC 3.6.3.16; EC 3.6.-.-; Hydrolase; Nucleolus

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: endoplasmic reticulum; cytoplasm; nucleolus; nucleus

Molecular Function: arsenite transmembrane transporter activity; transporter activity; metal ion binding; ATPase activity; ATP binding

Biological Process: protein insertion into ER membrane; inorganic anion transport; transport; metabolic process