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Natriuretic Peptide C (NPPC) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146114

Description: NPPC Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 126 amino acids (24-126) and having a molecular mass of 13.2kDa.NPPC is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary… More details

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Product Overview

Online Datasheet in PDF
Product Name
Natriuretic Peptide C (NPPC), Recombinant Protein
Full Product Name
Recombinant Human Natriuretic Peptide C
Product Gene Name
NPPC recombinant protein
Product Synonym Names
NPPC Human; Natriuretic Peptide C Human Recombinant; Natriuretic Peptide Precursor C; C-Type Natriuretic Peptide; CNP2; CNP
Sequence
MGSSHHH HHH SSGLVPRGSH MGSKPG APPK VPRTPPAEEL AEPQAAGGGQ KKGDKAPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS MSGLGC
Host
E Coli
Form/Format
The NPPC solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 85% as determined by SDS-PAGE.
Molecular Weight
13,246 Da
OMIM
600296
3D Structure
ModBase 3D Structure for P23582

Product Categories/Family for NPPC recombinant protein

Cytokines and Growth Factors; Cytokines; B type Natriuretic Peptide

Other Notes

Small volumes of NPPC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPPC purchase

MBS146114 is a recombinant protein targeting NPPC. Also known as Recombinant Human Natriuretic Peptide C. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NPPC. It may not necessarily be applicable to this product.

NCBI GI #
13249346
NCBI GeneID
4880
NCBI Accession #
NP_077720.1
UniProt Primary Accession #
P23582
UniProt Secondary Accession #
Q4ZG41
UniProt Related Accession #
P23582
GenBank Nucleotide #
NM_024409.2
NCBI Official Full Name
C-type natriuretic peptide
NCBI Official Synonym Full Names
natriuretic peptide C
NCBI Official Symbol
NPPC
NCBI Official Synonym Symbols
CNP; CNP2
UniProt Protein Name
C-type natriuretic peptide
Protein Family
C-type natriuretic peptide
UniProt Gene Name
NPPC
UniProt Synonym Gene Names
CNP2
UniProt Entry Name
ANFC_HUMAN
NCBI Protein Information
C-type natriuretic peptide; natriuretic peptide precursor C

NCBI Summary for NPPC

The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic. [provided by RefSeq, Sep 2011]
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UniProt Comments for NPPC

NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Secreted, signal peptide; Hormone; Secreted

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: extracellular space; secretory granule

Molecular Function: protein homodimerization activity; peptide hormone receptor binding; hormone activity; receptor binding

Biological Process: response to drug; negative regulation of cell proliferation; positive regulation of osteoblast differentiation; cGMP biosynthetic process; ossification; response to ethanol; regulation of smooth muscle cell proliferation; positive regulation of cGMP biosynthetic process; regulation of cAMP metabolic process; receptor guanylyl cyclase signaling pathway; response to hypoxia; regulation of multicellular organism growth; negative regulation of meiotic cell cycle; regulation of cGMP metabolic process; negative regulation of DNA metabolic process; regulation of blood vessel size; positive regulation of vasodilation; post-embryonic development
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Research Articles on NPPC

1. Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NPPC recombinant protein

 Reference Product  PubMed Publications
 NPR2 recombinant protein  >21 publications with NPPC and NPR2
 NPPA recombinant protein  >9 publications with NPPC and NPPA
 NPPB recombinant protein  >7 publications with NPPC and NPPB
 NPR3 recombinant protein  >7 publications with NPPC and NPR3
 NPR1 recombinant protein  >4 publications with NPPC and NPR1

Diseases associated with NPPC recombinant protein

 Disease Name  Pubmed Publications
 Bone Diseases, Developmental Antibodies  >7 publications with NPPC and Bone Diseases, Developmental
 Nervous System Diseases Antibodies  >5 publications with NPPC and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with NPPC and Brain Diseases
 Cardiovascular Diseases Antibodies  >4 publications with NPPC and Cardiovascular Diseases
 Growth Disorders Antibodies  >4 publications with NPPC and Growth Disorders
 Hypertension Antibodies  >3 publications with NPPC and Hypertension
 Disease Models, Animal Antibodies  >3 publications with NPPC and Disease Models, Animal
 Weight Gain Antibodies  >3 publications with NPPC and Weight Gain
 Heart Diseases Antibodies  >3 publications with NPPC and Heart Diseases
 Cartilage Diseases Antibodies  >3 publications with NPPC and Cartilage Diseases

Organs/Tissues associated with NPPC recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with NPPC and Skin
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