Human UQCRC2 Recombinant Protein – Cat# MBS146118

Ubiquinol-Cytochrome C Reductase Core Protein II (UQCRC2) Human Recombinant Protein

Name: UQCRC2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146118
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146118

Description: UQCRC2 Human Recombinant produced in E Coli is a single polypeptide chain containing 460 amino acids (15-453) and having a molecular mass of 49.0 kDa.UQCRC2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ubiquinol-Cytochrome C Reductase Core Protein II (UQCRC2), Recombinant Protein

Full Product Name

Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein II

Product Gene Name

UQCRC2 recombinant protein

Product Synonym Names

UQCRC2 Human; Ubiquinol-Cytochrome C Reductase Core Protein II Human Recombinant; Ubiquinol-Cytochrome C Reductase Core Protein II; Ubiquinol-Cytochrome-C Reductase Complex Core Protein 2; Cytochrome B-C1 Complex Subunit 2 Mitochondrial; Complex III Subunit 2; Core Protein II; UQCR2; QCR2

Sequence

MGSSHHH HHH SSGLVPRGSH MSLKVA PKVK ATAAPAGAPP QPQDLEFTKL PNGLVIASLE NYSPVSRIGL FIKAGSRYED FSNLGTTHLL RLTSSLTTKG ASSFKITRGI EAVGGKLSVT ATRENMAYTV ECLRGDVDIL MEFLLNVTTA PEFRRWEVAD LQPQLKIDKA VAFQNPQTHV IENLHAAAYR NALANPLYCP DYRIGKVTSE ELHYFVQNHF TSARMALIGL GVSHPVLKQV AEQFLNMRGG LGLSGAKANY RGGEIREQNG DSLVHAAFVA ESAVAGSAEA NAFSVLQHVL GAGPHVKRGS NTTSHLHQAV AKATQQPFDV SAFNASYSDS GLFGIYTISQ ATAAGDVIKA AYNQVKTIAQ GNLSNTDVQA AKNKLKAGYL MSVESSECFL EEVGSQALVA GSYMPPSTVL QQIDSVANAD IINAAKKFVS GQKSMAASGN LGHTPFVDEL

Host

E Coli

Form/Format

The UQCRC2 solution contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea, 0.1M NaCl and 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 85% as determined by SDS-PAGE.

Molecular Weight

48,443 Da

OMIM

191329

3D Structure

ModBase 3D Structure for P22695

Product Categories/Family for UQCRC2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Ubiquinol-Cytochrome C Reductase

Other Notes

Small volumes of UQCRC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UQCRC2 purchase

MBS146118 is a recombinant protein targeting UQCRC2. Also known as Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein II. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for UQCRC2. It may not necessarily be applicable to this product.

NCBI GI #

50592988

NCBI GeneID

7385

NCBI Accession #

NP_003357.2

UniProt Primary Accession #

P22695

UniProt Secondary Accession #

Q9BQ05; B3KSN4

UniProt Related Accession #

P22695

GenBank Nucleotide #

NM_003366.2

NCBI Official Full Name

cytochrome b-c1 complex subunit 2, mitochondrial

NCBI Official Synonym Full Names

ubiquinol-cytochrome c reductase core protein II

NCBI Official Symbol

UQCRC2

NCBI Official Synonym Symbols

QCR2; UQCR2; MC3DN5

UniProt Protein Name

Cytochrome b-c1 complex subunit 2, mitochondrial

UniProt Synonym Protein Names

Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2

UniProt Gene Name

UQCRC2

UniProt Entry Name

QCR2_HUMAN

NCBI Protein Information

cytochrome b-c1 complex subunit 2, mitochondrial; complex III subunit 2; core protein II; ubiquinol-cytochrome-c reductase complex core protein 2

NCBI Summary for UQCRC2

The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]

UniProt Comments for UQCRC2

UQCRC2: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.

Protein type: Mitochondrial; EC 1.10.2.2; Energy Metabolism - oxidative phosphorylation; Oxidoreductase

Chromosomal Location of Human Ortholog: 16p12

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial respiratory chain complex III

Molecular Function: protein binding; metal ion binding; metalloendopeptidase activity; protein complex binding

Biological Process: cellular metabolic process; aerobic respiration; proteolysis; oxidative phosphorylation

Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 5

Research Articles on UQCRC2

1. These data indicate that a homozygous missense mutation in UQCRC2 causes moderately impaired CIII function and severely decreased amounts of CIII and supercomplex, which would be the primary molecular pathogenesis in the patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with UQCRC2 recombinant protein

Reference Product	PubMed Publications
UQCRC1 recombinant protein	>4 publications with UQCRC2 and UQCRC1
MT-CO1 recombinant protein	>1 publications with UQCRC2 and MT-CO1
UQCRH recombinant protein	>1 publications with UQCRC2 and UQCRH
UQCRQ recombinant protein	>1 publications with UQCRC2 and UQCRQ
CYC1 recombinant protein	>1 publications with UQCRC2 and CYC1

Pathways associated with UQCRC2 recombinant protein

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cytochrome Bc1 Complex Pathway antibodies	Cytochrome Bc1 Complex Pathway Diagram
Cytochrome Bc1 Complex Pathway antibodies	Cytochrome Bc1 Complex Pathway Diagram
Electron Transport Chain Pathway antibodies	Electron Transport Chain Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram

Diseases associated with UQCRC2 recombinant protein

Disease Name	Pubmed Publications
Mitochondrial Diseases Antibodies	>3 publications with UQCRC2 and Mitochondrial Diseases
Death Antibodies	>2 publications with UQCRC2 and Death
Disease Models, Animal Antibodies	>2 publications with UQCRC2 and Disease Models, Animal
Genital Diseases, Male Antibodies	>1 publications with UQCRC2 and Genital Diseases, Male
Nervous System Diseases Antibodies	>1 publications with UQCRC2 and Nervous System Diseases
Abnormalities, Drug-Induced Antibodies	>1 publications with UQCRC2 and Abnormalities, Drug-Induced
Adenocarcinoma Antibodies	>1 publications with UQCRC2 and Adenocarcinoma
Neoplasms, Experimental Antibodies	>1 publications with UQCRC2 and Neoplasms, Experimental
Inflammation Antibodies	>1 publications with UQCRC2 and Inflammation

Organs/Tissues associated with UQCRC2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with UQCRC2 and Brain
Spinal Cord Antibodies	>1 publications with UQCRC2 and Spinal Cord
Nerve Antibodies	>1 publications with UQCRC2 and Nerve
Epididymis Antibodies	>1 publications with UQCRC2 and Epididymis
Muscle Antibodies	>1 publications with UQCRC2 and Muscle
Embryonic Tissue Antibodies	>1 publications with UQCRC2 and Embryonic Tissue
Liver Antibodies	>1 publications with UQCRC2 and Liver
Lung Antibodies	>1 publications with UQCRC2 and Lung
Heart Antibodies	>1 publications with UQCRC2 and Heart